ArticleBacteriophage2012
Dualities in the analysis of phage DNA packaging motors.
Article in Bacteriophage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Genomic characterization of novel lytic bacteriophages targeting carbapenemase producing multidrug resistant Klebsiella pneumoniae from Ethiopia: a molecular study.BMC microbiology · 2026Article
- Mechanism of Viral DNA Packaging in Phage T4 Using Single-Molecule Fluorescence Approaches.Viruses · 2024Review
- Viral Small Terminase: A Divergent Structural Framework for a Conserved Biological Function.Viruses · 2022Review
- A Perspective on Studies of Phage DNA Packaging Dynamics.International journal of molecular sciences · 2022Article
- Review
- Simulations of Phage T7 Capsid Expansion Reveal the Role of Molecular Sterics on Dynamics.Viruses · 2020Article
- Electron Microscopy of In-Plaque Phage T3 Assembly: Proposed Analogs of Neurodegenerative Disease Triggers.Pharmaceuticals (Basel, Switzerland) · 2020Article
- A viral small terminase subunit (TerS) twin ring pac synapsis DNA packaging model is supported by fluorescent fusion proteins.Virology · 2019Article
- DNA Conformational Changes Play a Force-Generating Role during Bacteriophage Genome Packaging.Biophysical journal · 2019Article
- States of phage T3/T7 capsids: buoyant density centrifugation and cryo-EM.Biophysical reviews · 2018Review
- DNA Scrunching in the Packaging of Viral Genomes.The journal of physical chemistry. B · 2016Article
- Testing a proposed paradigm shift in analysis of phage DNA packaging.Bacteriophage · 2016Article
- Review
- The scrunchworm hypothesis: transitions between A-DNA and B-DNA provide the driving force for genome packaging in double-stranded DNA bacteriophages.Journal of structural biology · 2015Article
- Evidence for an electrostatic mechanism of force generation by the bacteriophage T4 DNA packaging motor.Nature communications · 2014Article
- Length quantization of DNA partially expelled from heads of a bacteriophage T3 mutant.Virology · 2014Article
- The XXIIIrd Phage/Virus Assembly Meeting.Bacteriophage · 2014Article
- Structural characterization of the bacteriophage T7 tail machinery.The Journal of biological chemistry · 2013Article
- Enhancing and initiating phage-based therapies.BacteriophageArticle
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Authors and funding
2 authors.
Funding
Abstract
The DNA packaging motors of double-stranded DNA phages are models for analysis of all multi-molecular motors and for analysis of several fundamental aspects of biology, including early evolution, relationship of in vivo to in vitro biochemistry and targets for anti-virals. Work on phage DNA packaging motors both has produced and is producing dualities in the interpretation of data obtained by use of both traditional techniques and the more recently developed procedures of single-molecule analysis. The dualities include (1) reductive vs. accretive evolution, (2) rotation vs. stasis of sub-assemblies of the motor, (3) thermal ratcheting vs. power stroking in generating force, (4) complete motor vs. spark plug role for the packaging ATPase, (5) use of previously isolated vs. new intermediates for analysis of the intermediate states of the motor and (6) a motor with one cycle vs. a motor with two cycles. We provide background for these dualities, some of which are under-emphasized in the literature. We suggest directions for future research.
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