ArticleScientific reports2013
Nanotopography-mediated reverse uptake for siRNA delivery into neural stem cells to enhance neuronal differentiation.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 72 citations in OpenAlex.
- Inorganic Nanoparticles-based Drug Delivery Systems for Neurodegenerative Diseases Therapy.Current pharmaceutical design · 2025Review
- Advanced Drug Delivery Modulation via Hybrid Nanofibers Enhances Stem Cell Differentiation.ACS applied materials & interfaces · 2022Article
- Water-Soluble, Alanine-Modified Fullerene CInternational journal of molecular sciences · 2022Article
- Stimulation of neural stem cell differentiation by circularly polarized light transduced by chiral nanoassemblies.Nature biomedical engineering · 2021Article
- Regulation of Stem Cell Differentiation by Inorganic Nanomaterials: Recent Advances in Regenerative Medicine.Frontiers in bioengineering and biotechnology · 2021Review
- Small interfering RNA for cancer treatment: overcoming hurdles in delivery.Acta pharmaceutica Sinica. B · 2020Review
- Nanoparticle technology and stem cell therapy team up against neurodegenerative disorders.Advanced drug delivery reviews · 2019Review
- Efficient siRNA delivery and gene silencing using a lipopolypeptide hybrid vector mediated by a caveolae-mediated and temperature-dependent endocytic pathway.Journal of nanobiotechnology · 2019Article
- Regulation of Neural Stem Cell Proliferation and Differentiation by Graphene-Based Biomaterials.Neural plasticity · 2019Review
- RNA-silencing nanoprobes for effective activation and dynamic imaging of neural stem cell differentiation.Theranostics · 2019Article
- Nanostructured Lipid-based Films for Substrate Mediated Applications in Biotechnology.Advanced functional materials · 2018Article
- Functionalization of microparticles with mineral coatings enhances non-viral transfection of primary human cells.Scientific reports · 2017Article
- Nanotechnology for Neuroscience: Promising Approaches for Diagnostics, Therapeutics and Brain Activity Mapping.Advanced functional materials · 2017Article
- Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases.Genes · 2017Review
- Article
- Nanotechnology-Based Approaches for Guiding Neural Regeneration.Accounts of chemical research · 2016Article
- The nanomaterial toolkit for neuroengineering.Nano convergence · 2016Review
- Induction of stem-cell-derived functional neurons by NanoScript-based gene repression.Angewandte Chemie (International ed. in English) · 2015Article
- Surface-mediated delivery of siRNA from fibrin hydrogels for knockdown of the BMP-2 binding antagonist noggin.Acta biomaterialia · 2015Article
- Design, synthesis, and characterization of graphene-nanoparticle hybrid materials for bioapplications.Chemical reviews · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
RNA interference (RNAi) for controlling gene expression levels using siRNA or miRNA is emerging as an important tool in stem cell biology. However, the conventional methods used to deliver siRNA into stem cells result in significant cytotoxicity and undesirable side-effects. To this end, we have developed a nanotopography-mediated reverse uptake (NanoRU) delivery platform to demonstrate a simple and efficient technique for delivering siRNA into neural stem cells (NSCs). NanoRU consists of a self-assembled silica nanoparticle monolayer coated with extracellular matrix proteins and the desired siRNA. We use this technique to efficiently deliver siRNA against the transcription factor SOX9, which acts as a switch between neuronal and glial fate of NSCs. The knockdown of SOX9 enhanced the neuronal differentiation and decreased the glial differentiation of the NSCs. Our NanoRU platform demonstrates a novel application and the importance of nanotopography-mediated siRNA delivery into stem cells as an effective method for genetic manipulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.