ArticleEuropean journal of human genetics : EJHG2013
Population structure, migration, and diversifying selection in the Netherlands.
Article in European journal of human genetics : EJHG, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 2 of them syntheses that pooled it.
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Who cites it
82 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course.Behavior genetics · 2021Pooled it
- Replicability and robustness of genome-wide-association studies for behavioral traits.Psychological science · 2014Pooled it
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- Ancient DNA suggests a historical demographic decline and genetic erosion in the Atlantic bluefin tuna.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Urbanization and genetic homogenization in the medieval Low Countries revealed through a ten-century paleogenomic study of the city of Sint-Truiden.Genome biology · 2025Article
- Socio-economic status is a social construct with heritable components and genetic consequences.Nature human behaviour · 2025Review
- Social Mismatch and Affective Wellbeing: An Ecological Momentary Assessment Study.Journal of happiness studies · 2025Article
- Exploring first-degree family history in a cohort of Portuguese Alzheimer's disease patients: population evidence for X-chromosome linked and recessive inheritance of risk factors.Journal of neurology · 2024Article
- Intergenerational transmission of genetic risk for hyperactivity and inattention. Direct genetic transmission or genetic nurture?JCPP advances · 2024Article
- Adjusting for principal components can induce spurious associations in genome-wide association studies in admixed populations.bioRxiv : the preprint server for biology · 2024Article
- Phylogeography, origin and population structure of the self-fertile emerging plant pathogen Phytophthora pseudosyringae.Molecular plant pathology · 2024Article
- No gene by stressful life events interaction on individual differences in adults' self-control.Frontiers in psychiatry · 2024Article
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- Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy.Scientific reports · 2023Article
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- Phylogeography and population structure of the global, wide host-range hybrid pathogen Phytophthora × cambivora.IMA fungus · 2023Article
22 more citing papers are in PubMed but not listed here.
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17 authors.
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Abstract
Genetic variation in a population can be summarized through principal component analysis (PCA) on genome-wide data. PCs derived from such analyses are valuable for genetic association studies, where they can correct for population stratification. We investigated how to capture the genetic population structure in a well-characterized sample from the Netherlands and in a worldwide data set and examined whether (1) removing long-range linkage disequilibrium (LD) regions and LD-based SNP pruning significantly improves correlations between PCs and geography and (2) whether genetic differentiation may have been influenced by migration and/or selection. In the Netherlands, three PCs showed significant correlations with geography, distinguishing between: (1) North and South; (2) East and West; and (3) the middle-band and the rest of the country. The third PC only emerged with minimized LD, which also significantly increased correlations with geography for the other two PCs. In addition to geography, the Dutch North-South PC showed correlations with genome-wide homozygosity (r=0.245), which may reflect a serial-founder effect due to northwards migration, and also with height (♂: r=0.142, ♀: r=0.153). The divergence between subpopulations identified by PCs is partly driven by selection pressures. The first three PCs showed significant signals for diversifying selection (545 SNPs - the majority within 184 genes). The strongest signal was observed between North and South for the functional SNP in HERC2 that determines human blue/brown eye color. Thus, this study demonstrates how to increase ancestry signals in a relatively homogeneous population and how those signals can reveal evolutionary history.
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