ArticleSubstance abuse : research and treatment2013
A Comparison of Buprenorphine + Naloxone to Buprenorphine and Methadone in the Treatment of Opioid Dependence during Pregnancy: Maternal and Neonatal Outcomes.
Article in Substance abuse : research and treatment, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03740243 (Comparison of Buprenorphine vs Buprenorphine/Naloxone on the Effects of Maternal Symptomatology), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Buprenorphine vs Buprenorphine/Naloxone on the Effects of Maternal Symptomatology
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Guideline
- United States county jail treatment and care of pregnant incarcerated persons with opioid use disorder.Drug and alcohol dependence · 2023Article
- Buprenorphine-naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Long-term treatment retention in West Virginia's comprehensive opioid addiction treatment (COAT) program.Journal of the neurological sciences · 2020Review
- Advancing preventive interventions for pregnant women who are opioid using via the integration of addiction and mental health research.Current addiction reports · 2020Article
- West Virginia's model of buprenorphine expansion: Preliminary results.Journal of substance abuse treatment · 2020Article
- Neonatal abstinence syndrome.Nature reviews. Disease primers · 2018Review
- Neonatal outcomes after fetal exposure to methadone and buprenorphine: national registry studies from the Czech Republic and Norway.Addiction (Abingdon, England) · 2018Article
- Treating women with opioid use disorder during pregnancy in Appalachia: Initial neonatal outcomes following buprenorphine + naloxone exposure.The American journal on addictions · 2018Article
- Opioid use in pregnancy and parenting: An Indigenous-based, collaborative framework for Northwestern Ontario.Canadian journal of public health = Revue canadienne de sante publique · 2018Article
- Review
- Primary care management of opioid use disorders: Abstinence, methadone, or buprenorphine-naloxone?Canadian family physician Medecin de famille canadien · 2017Review
- An overview of available drugs for management of opioid abuse during pregnancy.Maternal health, neonatology and perinatology · 2017Review
- Observational study of the safety of buprenorphine+naloxone in pregnancy in a rural and remote population.BMJ open · 2016Observational
- Naloxone and Metabolites Quantification in Cord Blood of Prenatally Exposed Newborns and Correlations with Maternal Concentrations.AJP reports · 2016Article
- Opioids in pregnancy and neonatal abstinence syndrome.Seminars in perinatology · 2015Review
- Gender Considerations in Addiction: Implications for Treatment.Current treatment options in psychiatry · 2015Article
- The management of opioid dependence during pregnancy in rural and remote settings.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2015Review
- Safety of the newer class of opioid antagonists in pregnancy.Canadian family physician Medecin de famille canadien · 2014Article
- Clinical care for opioid-using pregnant and postpartum women: the role of obstetric providers.American journal of obstetrics and gynecology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Given that buprenorphine + naloxone is prescribed for opioid-dependent pregnant women, it is important to examine the extent to which it differs from buprenorphine alone, methadone, or methadone-assisted withdrawal on neonatal and maternal outcomes. Summary statistics on maternal and neonatal outcomes were collected from 7 previously published studies examining treatment for opioid-dependent pregnant women that represented a range of research methodologies. Outcomes from these studies were compared to the same outcomes for 10 women treated with the combined buprenorphine + naloxone product. There were no significant differences in maternal outcomes for buprenorphine + naloxone compared to buprenorphine, methadone, or methadone-assisted withdrawal. Preliminary findings suggest no significant adverse maternal or neonatal outcomes related to the use of buprenorphine + naloxone for the treatment of opioid dependence during pregnancy. However, further research should examine possible differences between buprenorphine + naloxone and buprenorphine alone or methadone in fetal physical development.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.