Evidence map›Paper›PMID 23531697›Full record

ReviewNature reviews. Neuroscience2013

Imaging structural co-variance between human brain regions.

Aaron Alexander-Bloch, Jay N Giedd, Ed Bullmore

Abstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 596 papers.

0numbers the graph read from it
0cells of the map it votes in
596citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

596 citing papers in PubMed.

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  11. Normative THuman brain mapping · 2026
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536 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aaron Alexander-BlochChild Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA. aalexanderbloch@gmail.com
Jay N Giedd
Ed Bullmore

Funding

Pediatric Brain ImagingZIAMH002794 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI RAPOPORT, JUDITH L. · 2009 to 2015
$15.3M
Intramural NIH HHS Z99 MH999999Medical Research Council G0001354Wellcome Trust
6 · The paper itself

Abstract

Brain structure varies between people in a markedly organized fashion. Communities of brain regions co-vary in their morphological properties. For example, cortical thickness in one region influences the thickness of structurally and functionally connected regions. Such networks of structural co-variance partially recapitulate the functional networks of healthy individuals and the foci of grey matter loss in neurodegenerative disease. This architecture is genetically heritable, is associated with behavioural and cognitive abilities and is changed systematically across the lifespan. The biological meaning of this structural co-variance remains controversial, but it appears to reflect developmental coordination or synchronized maturation between areas of the brain. This Review discusses the state of current research into brain structural co-variance, its underlying mechanisms and its potential value in the understanding of various neurological and psychiatric conditions.

Indexed as

Brain MappingAgingBrainHumansLongevityNerve NetNeural PathwaysNeuroimaging

Identifiers

PMID23531697
PMCPMC4043276

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.