ArticleAmerican journal of physiology. Endocrinology and metabolism2013
Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin.
Article in American journal of physiology. Endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Effects of Berberine on Lipid Metabolism, Antioxidant Status, and Immune Response in Liver of Tilapia (Antioxidants (Basel, Switzerland) · 2024Article
- Lipotoxicity and immunometabolism in ischemic acute kidney injury: current perspectives and future directions.Frontiers in pharmacology · 2024Review
- Palmitate Stimulates Expression of the von Willebrand Factor and Modulates Toll-like Receptors Level and Activity in Human Umbilical Vein Endothelial Cells (HUVECs).International journal of molecular sciences · 2023Article
- Opposing Actions of TLR2 and TLR4 in Adipocyte Differentiation and Mature-Onset Obesity.International journal of molecular sciences · 2022Article
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- The Induction of Endothelial Autophagy and Its Role in the Development of Atherosclerosis.Frontiers in cardiovascular medicine · 2022Review
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- Novel Insights Into the Pathogenesis of Diabetic Cardiomyopathy and Pharmacological Strategies.Frontiers in cardiovascular medicine · 2021Review
- Long-chain acyl-CoA synthetase-1 mediates the palmitic acid-induced inflammatory response in human aortic endothelial cells.American journal of physiology. Endocrinology and metabolism · 2020Article
- Metformin reduces saturated fatty acid-induced lipid accumulation and inflammatory response by restoration of autophagic flux in endothelial cells.Scientific reports · 2020Article
- Saturated Fatty Acids in Obesity-Associated Inflammation.Journal of inflammation research · 2020Review
- Deletion of interleukin 1 receptor-associated kinase 1 (The Journal of biological chemistry · 2017Article
- TLR2 knockout protects against diabetes-mediated changes in cerebral perfusion and cognitive deficits.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2.Nature communications · 2017Article
- Cerebrovascular complications of diabetes: focus on cognitive dysfunction.Clinical science (London, England : 1979) · 2016Review
- Maternal Hyperleptinemia Is Associated with Male Offspring's Altered Vascular Function and Structure in Mice.PloS one · 2016Article
- Toll-like receptor 4-induced endoplasmic reticulum stress contributes to impairment of vasodilator action of insulin.American journal of physiology. Endocrinology and metabolism · 2015Article
- Gene expression profiling and association of circulating lactoferrin level with obesity-related phenotypes in Latino youth.Pediatric obesity · 2015Article
- Protective role of oleic acid against cardiovascular insulin resistance and in the early and late cellular atherosclerotic process.Cardiovascular diabetology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Obesity is characterized by a chronic proinflammatory state that leads to endothelial dysfunction. Saturated fatty acids (SFA) stimulate Toll-like receptors (TLR) that promote metabolic insulin resistance. However, it is not known whether TLR2 mediates impairment of vascular actions of insulin in response to high-fat diet (HFD) to cause endothelial dysfunction. siRNA knockdown of TLR2 in primary endothelial cells opposed palmitate-stimulated expression of proinflammatory cytokines and splicing of X box protein 1 (XBP-1). Inhibition of unfolding protein response (UPR) reduced SFA-stimulated expression of TNFα. Thus, SFA stimulates UPR and proinflammatory response through activation of TLR2 in endothelial cells. Knockdown of TLR2 also opposed impairment of insulin-stimulated phosphorylation of eNOS and subsequent production of NO. Importantly, insulin-stimulated vasorelaxation of mesenteric arteries from TLR2 knockout mice was preserved even on HFD (in contrast with results from arteries examined in wild-type mice on HFD). We conclude that TLR2 in vascular endothelium mediates HFD-stimulated proinflammatory responses and UPR that accompany impairment of vasodilator actions of insulin, leading to endothelial dysfunction. These results are relevant to understanding the pathophysiology of the cardiovascular complications of diabetes and obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.