ArticleMolecules (Basel, Switzerland)2013
Effects of freshwater clam extract supplementation on time to exhaustion, muscle damage, pro/anti-inflammatory cytokines, and liver injury in rats after exhaustive exercise.
Article in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- The Effects of Freshwater Clam (Marine drugs · 2022Trial
- Bioactive nanoparticles from clam extracts mitigate alcoholic liver injury by modulating multiple pathways.NPJ science of food · 2026Article
- Article
- Ginsenosides, salidroside, and syringin complex exhibits anti-fatigue in exhaustive exercise rats.International journal of medical sciences · 2025Article
- The Synergistic Effects ofAntioxidants (Basel, Switzerland) · 2023Article
- Tropomyosin micelles are the major components contributing to the white colour of boiled shellfish soups.Scientific reports · 2022Article
- Freshwater Clam Extract Mitigates Neuroinflammation and Amplifies Neurotrophic Activity of Glia: Insights from In Vitro Model of Neurodegenerative Pathomechanism.Journal of clinical medicine · 2022Article
- Dihydromyricetin-Encapsulated Liposomes Inhibit Exhaustive Exercise-Induced Liver Inflammation by Orchestrating M1/M2 Macrophage Polarization.Frontiers in pharmacology · 2022Article
- The Effects of Freshwater Clam (Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Mangosteen Concentrate Drink Supplementation Promotes Antioxidant Status and Lactate Clearance in Rats after Exercise.Nutrients · 2020Article
- Protective Effects of Resveratrol Supplementation on Contusion Induced Muscle Injury.International journal of medical sciences · 2020Article
- Fatty Acid, Lipid Classes and Phospholipid Molecular Species Composition of the Marine ClamMolecules (Basel, Switzerland) · 2019Article
- Exercise and Garlic Modulate microRNAs Involved in Diabetic Cardiopathy.Arquivos brasileiros de cardiologia · 2019Article
- The Effect of Garlic and Voluntary Exercise on Cardiac Angiogenesis in Diabetes: The Role of MiR-126 and MiR-210.Arquivos brasileiros de cardiologia · 2019Article
- Nanobubbles Water Curcumin Extract Reduces Injury Risks on Drop Jumps in Women: A Pilot Study.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Effects of freshwater clam extract on fracture induced inflammation at early stage.Experimental and therapeutic medicine · 2017Article
- Effect of acute and chronic exercise on plasma matrix metalloproteinase and total antioxidant levels.Journal of exercise rehabilitation · 2017Article
- Cardioprotective Effect of Crocin Combined with Voluntary Exercise in Rat: Role of Mir-126 and Mir-210 in Heart Angiogenesis.Arquivos brasileiros de cardiologia · 2017Article
- Whey Protein Improves Marathon-Induced Injury and Exercise Performance in Elite Track Runners.International journal of medical sciences · 2017Article
- Macrophage depletion by clodronate liposome attenuates muscle injury and inflammation following exhaustive exercise.Biochemistry and biophysics reports · 2016Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The potent anti-inflammatory activities and tissue-protective effects of freshwater clams (Corbicula fluminea) have been well reported. The aim of this study was to determine the effects of freshwater clam extract (FCE) supplementation on time to exhaustion, muscle damage, pro- and anti-inflammatory cytokines, and liver injury in rats after exhaustive exercise. Thirty-two rats were divided into four groups: sedentary control (SC); SC group with FCE supplementation (SC+FCE); exhaustive exercise (E); and E group with FCE supplementation (E+FCE). The SC+FCE and E+FCE groups were treated with gavage administration of 20 mg/kg for seven consecutive days. Blood samples were collected for the evaluation of biochemical parameters. The cytokine levels of TNF-α and IL-10 were also examined. Twenty-four hours after exhaustive exercise, the rat livers were removed for H & E staining. The FCE supplementation could extend the time to exhaustion in exercised rats. The levels of CPK, LDH, AST, ALT, lactate, TNF-α and H & E stains of the liver injury were significantly decreased in the E+FCE group, but the blood glucose and IL-10 were significantly higher in comparison with the E group. This study suggests that FCE supplementation may improve endurance performance and reduce exercise-induced muscle damage, inflammatory stress and liver injury.
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