ArticleCritical care (London, England)2013
Leukocyte capture and modulation of cell-mediated immunity during human sepsis: an ex vivo study.
Article in Critical care (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Effects on mortality of different blood purification techniques in sepsis patients: an umbrella review of systematic reviews and meta-analyses.Renal failure · 2026Pooled it
- Removal of activated neutrophils by a polymyxin B-immobilized fiber (PMX) column.The International journal of artificial organs · 2026Article
- Proteins Adsorbed during Intraoperative Hemoadsorption and Their In Vitro Effects on Endothelium.Healthcare (Basel, Switzerland) · 2023Article
- Article
- Synthetic hydrogel nanoparticles for sepsis therapy.Nature communications · 2021Article
- Blood purification for sepsis: an overview.Precision clinical medicine · 2021Review
- Clearance of inflammatory cytokines in patients with septic acute kidney injury during renal replacement therapy using the EMiC2 filter (Clic-AKI study).Critical care (London, England) · 2021Observational
- Extracorporeal blood purification treatment options for COVID-19: The role of immunoadsorption.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2020Review
- Continuous renal replacement therapy in cytokine release syndrome following immunotherapy or cellular therapies?Journal for immunotherapy of cancer · 2020Review
- Granulocyte and monocyte adsorptive apheresis ameliorates sepsis in rats.Intensive care medicine experimental · 2017Article
- Continuous Renal Replacement Therapy: Forty-year Anniversary.The International journal of artificial organs · 2017Article
- Impaired coronary microcirculation in type 2 diabetic patients is associated with elevated circulating regulatory T cells and reduced number of IL-21R⁺ T cells.Cardiovascular diabetology · 2016Article
- IMMUNE CELL PHENOTYPE AND FUNCTION IN SEPSIS.Shock (Augusta, Ga.) · 2016Review
- Broad spectrum immunomodulation using biomimetic blood cell margination for sepsis therapy.Lab on a chip · 2016Article
- A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis.PLoS computational biology · 2015Article
- [Adsorption therapy in sepsis].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2015Review
- Characterization of Adsorbents for Cytokine Removal from Blood in an In Vitro Model.Journal of immunology research · 2015Article
- Effects of hemoadsorption with a novel adsorbent on sepsis: in vivo and in vitro study.Blood purification · 2015Article
- Use of a novel hemoadsorption device for cytokine removal as adjuvant therapy in a patient with septic shock with multi-organ dysfunction: A case study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2014Article
- Year in review 2013: Critical Care--sepsis.Critical care (London, England) · 2014Review
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14 authors at 2 institutions in 1 country.
Funding
Abstract
introductionPromising preclinical results have been obtained with blood purification therapies as adjuvant treatment for sepsis. However, the mechanisms by which these therapies exert beneficial effects remain unclear. Some investigators have suggested that removal of activated leukocytes from the circulation might help ameliorate remote organ injury. We designed an extracorporeal hemoadsorption device capable of capturing both cytokines and leukocytes in order to test the hypothesis that leukocyte capture would alter circulating cytokine profiles and influence immunological cell-cell interactions in whole blood taken from patients with sepsis.
methodsWe performed a series of ex vivo studies in 21 patients with septic shock and 12 healthy volunteers. Blood circulated for four hours in closed loops with four specially designed miniaturized extracorporeal blood purification devices including two different hemoadsorption devices and a hemofilter in order to characterize leukocyte capture and to assess the effects of leukocyte removal on inflammation and immune function.
resultsHemoadsorption was selective for removal of activated neutrophils and monocytes. Capture of these cells led to local release of certain cytokines, especially IL-8, and resulted in complex cell-cell interactions involved in cell-mediated immunity. Inhibition of cell adherence reversed the cytokine release and the effects on lymphocyte function.
conclusionsMonocyte and neutrophil capture using a sorbent polymer results in upregulation of IL-8 and modulation of cell-mediated immunity. Further studies are needed to understand better these cellular interactions in order to help design better blood purification therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.