ArticleCilia2013
The effect of ethanol and acetaldehyde on brain ependymal and respiratory ciliary beat frequency.
Article in Cilia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Redox regulation of motile cilia in airway disease.Redox biology · 2019Review
- Alcohol consumption impairs the ependymal cilia motility in the brain ventricles.Scientific reports · 2017Article
- Effects of histamine on ciliary beat frequency of ciliated cells from guinea pigs nasal mucosa.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2015Article
- Automated identification of abnormal respiratory ciliary motion in nasal biopsies.Science translational medicine · 2015Article
- Live Imaging of the Ependymal Cilia in the Lateral Ventricles of the Mouse Brain.Journal of visualized experiments : JoVE · 2015Article
- Three types of ependymal cells with intracellular calcium oscillation are characterized by distinct cilia beating properties.Journal of neuroscience research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEthanol has been shown to stimulate the beat frequency of respiratory cilia at concentrations encountered during social drinking, while one of its metabolites, acetaldehyde, has been shown to cause a marked decrease in ciliary beat frequency. The aim of this study was to determine whether short-term exposure to ethanol stimulated ependymal cilia and whether exposure to acetaldehyde had a toxic effect on ependymal and respiratory cilia.
methodsUsing ex vivo rat ependymal brain slice and human nasal brush biopsy models, we investigated the effect of exposure of cilia to various concentrations of ethanol and acetaldehyde at either 37°C or 24°C. Ciliary beat frequency was measured using digital high-speed video analysis.
resultsExposure of ependymal and respiratory cilia to control, 0.1%, 0.5% and 1% ethanol solutions resulted in a maximal increase of 15% in the ciliary beat frequency from baseline values, compared with the control of 6%. A one-way analysis of variance comparing the mean slopes for the three concentrations of ethanol and control showed no significant differences between the groups (P >0.05). Exposure of ependymal and respiratory cilia to 100 and 250 μM acetaldehyde solutions resulted in a maximal increase of 15% in the ciliary beat frequency from baseline, compared with the control of 12%. A one-way analysis of variance performed to compare the mean slopes in these groups showed no significant differences (P >0.05).
conclusionsShort-term exposure of brain ependymal and respiratory cilia to the concentrations of ethanol likely to be encountered during episodes of heavy drinking and to acetaldehyde at concentrations well above those encountered by man did not have a significant effect on ciliary beat frequency.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.