ArticleDiagnostic pathology2013
Variable Ki67 proliferative index in 65 cases of nodular fasciitis, compared with fibrosarcoma and fibromatosis.
Article in Diagnostic pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 26 citations in OpenAlex.
- Nodular fasciitis of the intradural cervical spine with *MIR22HG::USP6* fusion a rare postoperative occurrence and novel molecular pathogenesis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Histomorphological evaluation, cell proliferation and endothelial immunostaining in oral and maxillofacial myofibroblastic lesions.Medicina oral, patologia oral y cirugia bucal · 2022Article
- Nodular fasciitis: a comprehensive, time-correlated investigation of 17 cases.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- Sporadic intra-abdominal desmoid tumor with a very unusual onset: two case reports.Journal of medical case reports · 2021Article
- Desmoid tumor of the mesentery. Case report of a rare non-metastatic neoplasm.Medicine and pharmacy reports · 2021Article
- Article
- Comparative Analysis of the Histopathologic Features, β-Catenin, and Ki67 Expression between Fibromatosis and Fibrosarcoma.Journal of dentistry (Shiraz, Iran) · 2019Article
- Intra-articular nodular fasciitis: a rare lesion case report and an updated review of the literature.BMC musculoskeletal disorders · 2019Review
- Current diagnostics and treatment of fibrosarcoma -perspectives for future therapeutic targets and strategies.Oncotarget · 2017Review
- Description of a Rare Case of Nodular Fasciitis of the Apical Aspect of the Upper Buccal Sulcus.Case reports in dentistry · 2016Article
- Treatment of Nodular Fasciitis Occurring on the Face.Annals of dermatology · 2015Article
- Diagnostic challenges in primary orbital fibrosarcoma: a case report.Clinical ophthalmology (Auckland, N.Z.) · 2014Article
- A huge nodular fasciitis in parapharygneal space in a 7-year-old girl: a case report and review of literature.International journal of clinical and experimental pathology · 2014Review
- Gelatin sponge loaded with hypoxic human umbilical cord mesenchymal stem cell exosomes promotes healing of enterocutaneous fistula.Cell transplantationArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nodular fasciitis is the most common pseudosarcomatous lesion of soft tissue. Ki67 was considered as a useful marker for distinguishing some benign and malignant lesions. To study the usefulness of Ki67 in diagnosis of nodular fasciitis, the expression of Ki67 was examined by using immunostaining in 65 nodular fasciitis specimens, 15 desmoid fibromatosis specimens and 20 fibrosarcoma specimens. The results showed that there was a variable Ki67 index in all 65 cases of nodular fasciitis, and the mean labeling index was 23.71±15.01%. In majority (70.77%) of all cases,the index was ranged from 10% to 50%, in 6.15% (4/65) of cases the higher Ki67 index (over 50%) could be seen. The Ki67 proliferative index was closely related to duration of lesion, but not to age distribution, lesion size, sites of lesions and gender. Moreover, the mean proliferative index in desmoid fibromatosis and fibrosarcoma was 3.20±1.26% and 26.15±3.30% respectively. The mean Ki67 index of nodular fasciitis was not significantly lower than fibrosarcoma, but higher than desmoid fibromatosis. The variable and high Ki67 index in nodular fasciitis may pose a diagnostic challenge. We should not misdiagnose nodular fasciitis as a sarcoma because of its high Ki67 index. The recurrence of nodular fasciitis is rare; and the utility of Ki67 immunostaining may be not suitable for recurrence assessment in nodular fasciitis. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4782335818876666.
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