ArticleBMC biology2013
Thyroid hormone actions are temperature-specific and regulate thermal acclimation in zebrafish (Danio rerio).
Article in BMC biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 129 citations in OpenAlex.
- Ambient Developmental Temperatures and Maternal Thyroid Supply Promote Early Life Diversification in Salmonids.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2026Article
- Thyroid hormone determines energy efficiency of locomotion in zebrafish (Danio rerio) in a temperature-sensitive manner.The Journal of experimental biology · 2026Article
- Functional mutations in the thyroid-stimulating hormone receptor in natural stickleback populations at sites identical to human disease-causing mutations.BMC ecology and evolution · 2025Article
- Corticotropin-releasing hormone receptor 1 mediates the enhanced locomotor activity and metabolic demands to an acute thermal stress in adult zebrafish.Journal of neuroendocrinology · 2025Article
- Putative neural and endocrine control of thermal acclimation in fish.Conservation physiology · 2025Article
- The ecological function of thyroid hormones.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Thyroid hormone links environmental signals to DNA methylation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Developmental, physiologic and phylogenetic perspectives on the expression and regulation of myosin heavy chains in mammalian skeletal muscles.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Review
- Effects of Low Temperature on Antioxidant and Heat Shock Protein Expression Profiles and Transcriptomic Responses in Crayfish (Antioxidants (Basel, Switzerland) · 2022Article
- 3,5-T2-an Endogenous Thyroid Hormone Metabolite as Promising Lead Substance in Anti-Steatotic Drug Development?Metabolites · 2022Review
- Endocrine disruption from plastic pollution and warming interact to increase the energetic cost of growth in a fish.Proceedings. Biological sciences · 2022Article
- Transient Receptor Potential-Vanilloid (TRPV1-TRPV4) Channels in the Atlantic Salmon,Frontiers in physiology · 2021Article
- Bisphenols alter thermal responses and performance in zebrafish (Conservation physiology · 2021Article
- Plate-Based Respirometry to Assess Thermal Sensitivity of Zebrafish Embryo BioenergeticsFrontiers in physiology · 2021Article
- Experimental copper exposure, but not heat stress, leads to elevated intraovarian thyroid hormone levels in three-spined sticklebacks (Gasterosteus aculeatus).Ecotoxicology (London, England) · 2020Article
- Effects of a temperature rise on melatonin and thyroid hormones during smoltification of Atlantic salmon, Salmo salar.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Transcriptomic profiling revealed key signaling pathways for cold tolerance and acclimation of two carp species.BMC genomics · 2020Article
- Anthropogenic stressors impact fish sensory development and survival via thyroid disruption.Nature communications · 2020Article
- Mismatched light and temperature cues disrupt locomotion and energetics via thyroid-dependent mechanisms.Conservation physiology · 2020Article
- The Role of the Thyroid Axis in Fish.Frontiers in endocrinology · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThyroid hormone (TH) is best known for its role in development in animals, and for its control of metabolic heat production (thermogenesis) during cold acclimation in mammals. It is unknown whether the regulatory role of TH in thermogenesis is derived in mammals, or whether TH also mediates thermal responses in earlier vertebrates. Ectothermic vertebrates show complex responses to temperature variation, but the mechanisms mediating these are poorly understood. The molecular mechanisms underpinning TH action are very similar across vertebrates, suggesting that TH may also regulate thermal responses in ectotherms. We therefore aimed to determine whether TH regulates thermal acclimation in the zebrafish (Danio rerio). We induced hypothyroidism, followed by supplementation with 3,5-diiodothyronine (T2) or 3,5,3'-triiodothyronine (T3) in zebrafish exposed to different chronic temperatures. We measured whole-animal responses (swimming performance and metabolic rates), tissue-specific regulatory enzyme activities, gene expression, and free levels of T2 and T3.
resultsWe found that both T3 and the lesser-known T2, regulate thermal acclimation in an ectotherm. To our knowledge, this is the first such study to show this. Hypothyroid treatment impaired performance measures in cold-acclimated but not warm-acclimated individuals, whereas supplementation with both TH metabolites restored performance. TH could either induce or repress responses, depending on the actual temperature and thermal history of the animal.
conclusionsThe low sensitivity to TH at warm temperatures could mean that increasing temperatures (that is, global warming) will reduce the capacity of animals to regulate their physiologies to match demands. We suggest that the properties that underlie the role of TH in thermal acclimation (temperature sensitivity and metabolic control) may have predisposed this hormone for a regulatory role in the evolution of endothermy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.