Evidence map›Paper›PMID 23531004›Full record

ReviewAnnals of the New York Academy of Sciences2013

Imaging spinal neuron ensembles active during locomotion with genetically encoded calcium indicators.

Christopher A Hinckley, Samuel L Pfaff

Open access · greenAbstract readReview
In one paragraph

Review in Annals of the New York Academy of Sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Mapping the Dynamic Recruitment of Spinal Neurons during Fictive Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher A HinckleyHoward Hughes Medical Institute and Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Samuel L Pfaff
Howard Hughes Medical Institute · US

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Ye Zheng · 1985 to 2026
$82.8M
Genetic Control of Motor Neuron Development and FunctionR37NS037116 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI PFAFF, SAMUEL L. · 2007 to 2013
$3.6M
Proto-oncogenes in Axon GuidanceR01NS054172 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI PFAFF, SAMUEL L. · 2007 to 2011
$2.1M
Transgenic mice and bioinformatic tools to track astrocyte diversification insituR01MH099571 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI MARSALA, MARTIN, PFAFF, SAMUEL L. · 2013 to 2016
$1.7M
Howard Hughes Medical InstituteNCI NIH HHS P30 CA014195NIMH NIH HHS R01 MH099571NINDS NIH HHS R01 NS054172NINDS NIH HHS R37 NS037116
6 · The paper itself

Abstract

Advances in molecular-genetic tools for labeling neuronal subtypes, and the emerging development of robust genetic probes for neural activity, are likely to revolutionize our understanding of the functional organization of neural circuits. In principle, these tools should be able to detect activity at cellular resolution for large ensembles of identified neuron types as they participate in specific behaviors. This report describes the use of genetically encoded calcium indicators (GECIs), combined with two-photon microscopy, to characterize V1 interneurons, known to be critical for setting the duration of the step cycle. All V1 interneurons arise from a common precursor population and express engrailed-1 (En1). Our data show that although neighboring interneurons that arise from the same developmental lineage and share many features, such as projection patterns and neurotransmitter profiles, they are not irrevocably committed to having the same pattern of activity.

Indexed as

Genes, ReporterLocomotionOptical ImagingAnimalsAnimals, Genetically ModifiedCalcium SignalingHumansIndicators and ReagentsMotor NeuronsSpinal CordVoltage-Sensitive Dye ImagingIndicators and Reagents

Identifiers

PMID23531004
PMCPMC3908931
OpenAlexW1834662352

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.