ReviewAnnals of the New York Academy of Sciences2013
Principles of interneuron development learned from Renshaw cells and the motoneuron recurrent inhibitory circuit.
Review in Annals of the New York Academy of Sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed.
- Spatial and network principles behind neural generation of locomotion.Nature communications · 2026Article
- Molecularly diverse glycinergic interneurons in the medial deep dorsal horn are interposed between primary sensory afferents and spinal Shox2 interneurons.Frontiers in neural circuits · 2026Article
- Synaptic imbalance and increased inhibition impair motor function in SMA.Science advances · 2025Article
- Neuroanatomical and neurochemical atlas of the spiny mouse (Acomys cahirinus) spinal cord.Brain structure & function · 2025Article
- In vitro longitudinal lumbar spinal cord preparations to study sensory and recurrent motor microcircuits of juvenile mice.Journal of neurophysiology · 2022Article
- Spinal V1 neurons inhibit motor targets locally and sensory targets distally.Current biology : CB · 2021Article
- Article
- Using Machine Learning for Predicting the Best Outcomes With Electrical Muscle Stimulation for Tremors in Parkinson's Disease.Frontiers in aging neuroscience · 2021Article
- Comparison of gene expression profile of the spinal cord of sprouting-capable neonatal and sprouting-incapable adult mice.BMC genomics · 2019Article
- Motor units as tools to evaluate profile of human Renshaw inhibition.The Journal of physiology · 2019Article
- Subtype Diversification and Synaptic Specificity of Stem Cell-Derived Spinal Interneurons.Neuron · 2018Article
- Persistent Sodium Current Drives Excitability of Immature Renshaw Cells in Early Embryonic Spinal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Structure and Pharmacologic Modulation of Inhibitory Glycine Receptors.Molecular pharmacology · 2016Review
- Role of primary afferents in the developmental regulation of motor axon synapse numbers on Renshaw cells.The Journal of comparative neurology · 2016Article
- Decoding the organization of spinal circuits that control locomotion.Nature reviews. Neuroscience · 2016Review
- Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses.Pharmacological research · 2015Review
- An emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous system.Neural development · 2015Review
- Reduced Renshaw recurrent inhibition after neonatal sciatic nerve crush in rats.Neural plasticity · 2014Article
- Functional subpopulations of V3 interneurons in the mature mouse spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Axonal projections of Renshaw cells in the thoracic spinal cord.Physiological reports · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Renshaw cells provide a convenient model to study spinal circuit development during the emergence of motor behaviors with the goal of capturing principles of interneuron specification and circuit construction. This work is facilitated by a long history of research that generated essential knowledge about the characteristics that define Renshaw cells and the recurrent inhibitory circuit they form with motoneurons. In this review, we summarize recent data on the specification of Renshaw cells and their connections. A major insight from these studies is that the basic Renshaw cell phenotype is specified before circuit assembly, a result of their early neurogenesis and migration. Connectivity is later added, constrained by their placement in the spinal cord. Finally, different rates of synapse proliferation alter the relative weights of different inputs on postnatal Renshaw cells. Based on this work some general principles on the integration of spinal interneurons in developing motor circuits are derived.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.