ArticlePediatrics2013
Neuropsychological effects of konzo: a neuromotor disease associated with poorly processed cassava.
Article in Pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04036708 (Caregiver Early Child Development Training for Preventing Konzo From Toxic Cassava in the Democratic Republic of Congo), which is not on this map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Caregiver Early Child Development Training for Preventing Konzo From Toxic Cassava in the Democratic Republic of Congo (DRC)
Who cites it
31 citing papers in PubMed.
- Glutathione peroxidase 3 is a potential biomarker for konzo.Nature communications · 2024Article
- Children's cognitive impairment associated with cassava cyanide in Democratic Republic of the Congo: Burden of disease.PLOS global public health · 2024Article
- DNA methylation patterns associated with konzo in Sub-Saharan Africa.Clinical epigenetics · 2022Article
- Water Security and Nutrition: Current Knowledge and Research Opportunities.Advances in nutrition (Bethesda, Md.) · 2021Review
- The gut microbiome in konzo.Nature communications · 2021Observational
- Article
- Neurodevelopmental assessment at one year of age predicts neuropsychological performance at six years in a cohort of West African Children.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2021Article
- Motor control and cognition deficits associated with protein carbamoylation in food (cassava) cyanogenic poisoning: Neurodegeneration and genomic perspectives.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021Article
- Bitter taste receptors: Genes, evolution and health.Evolution, medicine, and public health · 2021Review
- Konzo: a distinct neurological disease associated with food (cassava) cyanogenic poisoning.Brain research bulletin · 2019Review
- [Socioemotional disorders in children living in Konzo-affected areas, an epidemic paralytic disease associated with cyanide poisoning from food in sub-Saharan Africa].The Pan African medical journal · 2018Article
- Dietary cyanogen exposure and early child neurodevelopment: An observational study from the Democratic Republic of Congo.PloS one · 2018Observational
- [Formula: see text]Selecting measures for the neurodevelopmental assessment of children in low- and middle-income countries.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2017Article
- Cognitive and motor performance in Congolese children with konzo during 4 years of follow-up: a longitudinal analysis.The Lancet. Global health · 2017Article
- Cassava, konzo, and neurotoxicity.The Lancet. Global health · 2017Article
- Lower sulfurtransferase detoxification rates of cyanide in konzo-A tropical spastic paralysis linked to cassava cyanogenic poisoning.Neurotoxicology · 2017Article
- Article
- Cyanide and the human brain: perspectives from a model of food (cassava) poisoning.Annals of the New York Academy of Sciences · 2016Review
- Use of the wetting method on cassava flour in three konzo villages in Mozambique reduces cyanide intake and may prevent konzo in future droughts.Food science & nutrition · 2016Article
- Constructing and Adapting Causal and Formative Measures of Family Settings: The HOME Inventory as Illustration.Journal of family theory & review · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundKonzo is an irreversible upper-motor neuron disorder affecting children dependent on bitter cassava for food. Although the neuroepidemiology of konzo is well characterized, we report the first neuropsychological findings.
methodChildren with konzo in the Democratic Republic of Congo (mean age 8.7 years) were compared with children without konzo (mean age 9.1 years) on the Kaufman Assessment Battery for Children, second edition (KABC-II), and the Bruininks-Oseretsky Test of Motor Proficiency, second edition (BOT-2). Both groups were also compared with normative KABC measures from earlier studies in a nearby nonkonzo region.
resultsUsing a Kruskal-Wallis test, children with konzo did worse on the KABC-II simultaneous processing (visual-spatial analysis) (K [1] = 8.78, P = .003) and mental processing index (MPI) (K [1] = 4.56, P = .03) than children without konzo. Both konzo and nonkonzo groups had poorer KABC sequential processing (memory) and MPI relative to the normative group from a nonkonzo region (K [2] = 75.55, P < .001). Children with konzo were lower on BOT-2 total (K [1] = 83.26, P < .001). KABC-II MPI and BOT-2 total were predictive of konzo status in a binary logistic regression model: odds ratio = 1.41, P < .013; 95% confidence interval 1.13-1.69.
conclusionsMotor proficiency is dramatically affected, and both children with and without konzo have impaired neurocognition compared with control children from a nonoutbreak area. This may evidence a subclinical neurocognitive form of the disease, extending the human burden of konzo with dramatic public health implications.
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