ArticleJournal of experimental botany2013
Chloroplast-localized 6-phosphogluconate dehydrogenase is critical for maize endosperm starch accumulation.
Article in Journal of experimental botany, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Whole-Genome Resequencing ofInternational journal of molecular sciences · 2026Article
- Evidence for peroxisomal redundancy among the glucose-6-phosphate dehydrogenase isoforms of Arabidopsis thaliana.Plant & cell physiology · 2025Article
- Comprehensive analysis of the physiological and molecular responses of phosphate-solubilizing bacteriumFrontiers in plant science · 2025Article
- Molecular mechanisms controlling grain size and weight and their biotechnological breeding applications in maize and other cereal crops.Journal of advanced research · 2024Review
- Maize and heat stress: Physiological, genetic, and molecular insights.The plant genome · 2024Review
- Article
- A role for heritable transcriptomic variation in maize adaptation to temperate environments.Genome biology · 2023Article
- Genetic Engineering of Starch Biosynthesis in Maize Seeds for Efficient Enzymatic Digestion of Starch during Bioethanol Production.International journal of molecular sciences · 2023Review
- Understanding Starch Metabolism in Pea Seeds towards Tailoring Functionality for Value-Added Utilization.International journal of molecular sciences · 2021Review
- The utility of metabolomics as a tool to inform maize biology.Plant communications · 2021Review
- Maize kernel development.Molecular breeding : new strategies in plant improvement · 2021Review
- Gm6PGDH1, a Cytosolic 6-Phosphogluconate Dehydrogenase, Enhanced Tolerance to Phosphate Starvation by Improving Root System Development and Modifying the Antioxidant System in Soybean.Frontiers in plant science · 2021Article
- Overexpression of a Cytosolic 6-Phosphogluconate Dehydrogenase Gene Enhances the Resistance of Rice toPlants (Basel, Switzerland) · 2020Article
- Maize endosperm-specific transcription factors O2 and PBF network the regulation of protein and starch synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Linkage disequilibrium, SNP frequency change due to selection, and association mapping in popcorn chromosome regions containing QTLs for quality traits.Genetics and molecular biology · 2016Article
- In Silico Analysis of Arabidopsis thaliana Peroxisomal 6-Phosphogluconate Dehydrogenase.Scientifica · 2016Article
- Proteomic Analyses Provide Novel Insights into Plant Growth and Ginsenoside Biosynthesis in Forest Cultivated Panax ginseng (F. Ginseng).Frontiers in plant science · 2016Article
- Improved evidence-based genome-scale metabolic models for maize leaf, embryo, and endosperm.Frontiers in plant science · 2015Article
- The cereal starch endosperm development and its relationship with other endosperm tissues and embryo.Protoplasma · 2015Review
- Metabolic control of redox and redox control of metabolism in plants.Antioxidants & redox signaling · 2014Review
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants have duplicate versions of the oxidative pentose phosphate pathway (oxPPP) enzymes with a subset localized to the chloroplast. The chloroplast oxPPP provides NADPH and pentose sugars for multiple metabolic pathways. This study identified two loss-of-function alleles of the Zea mays (maize) chloroplast-localized oxPPP enzyme 6-phosphogluconate dehydrogenase (6PGDH). These mutations caused a rough endosperm seed phenotype with reduced embryo oil and endosperm starch. Genetic translocation experiments showed that pgd3 has separate, essential roles in both endosperm and embryo development. Endosperm metabolite profiling experiments indicated that pgd3 shifts redox-related metabolites and increases reducing sugars similar to starch-biosynthetis mutants. Heavy isotope-labelling experiments indicates that carbon flux into starch is altered in pgd3 mutants. Labelling experiments with a loss of cytosolic 6PGDH did not affect flux into starch. These results support the known role for plastid-localized oxPPP in oil synthesis and argue that amyloplast-localized oxPPP reactions are integral to endosperm starch accumulation in maize kernels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.