ArticlePediatric obesity2014
Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort.
Article in Pediatric obesity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Cross-sectional and prospective impact of reallocating sedentary time to physical activity on children's body composition.Pediatric obesity · 2017Trial
- Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry.Human molecular genetics · 2015Trial
- Identification of SEC16B as a novel regulator of glucose homeostasis.Diabetologia · 2025Article
- Race, Ethnicity, and Geography as Determinants of Excessive Weight and Low Physical Activity in Pediatric Population: Protocol for Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2024Article
- How do lifestyle factors modify the association between genetic predisposition and obesity-related phenotypes? A 4-way decomposition analysis using UK Biobank.BMC medicine · 2024Article
- Do adverse childhood experiences and genetic obesity risk interact in relation to body mass index in young adulthood? Findings from the National Longitudinal Study of Adolescent to Adult Health.Pediatric obesity · 2022Article
- Inferring Gene-by-Environment Interactions with a Bayesian Whole-Genome Regression Model.American journal of human genetics · 2020Article
- Cohort Profile: The National Longitudinal Study of Adolescent to Adult Health (Add Health).International journal of epidemiology · 2019Article
- The Genetic Basis of Metabolic Disease.Cell · 2019Review
- A linear mixed-model approach to study multivariate gene-environment interactions.Nature genetics · 2019Article
- High birth weight modifies association between adolescent physical activity and cardiometabolic health in women and not men.Preventive medicine · 2018Article
- From genetics and epigenetics to the future of precision treatment for obesity.Gastroenterology report · 2017Review
- Differences in the Association of Physical Activity and Children's Overweight and Obesity Status Among the Major Racial and Ethnic Groups of U.S. Children.Health education & behavior : the official publication of the Society for Public Health Education · 2017Article
- The interaction between physical activity and obesity gene variants in association with BMI: Does the obesogenic environment matter?Health & place · 2016Article
- The importance of gene-environment interactions in human obesity.Clinical science (London, England : 1979) · 2016Review
- Influence of SNP*SNP interaction on BMI in European American adolescents: findings from the National Longitudinal Study of Adolescent Health.Pediatric obesity · 2016Article
- Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective.Molecular genetics and genomics : MGG · 2015Review
- Modification of genetic influences on adiposity between 36 and 63 years of age by physical activity and smoking in the 1946 British Birth Cohort Study.Nutrition & diabetes · 2014Article
- Screen time behaviours may interact with obesity genes, independent of physical activity, to influence adolescent BMI in an ethnically diverse cohort.Pediatric obesity · 2013Article
- Genotype by energy expenditure interaction with metabolic syndrome traits: the Portuguese healthy family study.PloS one · 2013Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLittle is known about the interaction between genetic and behavioural factors during lifecycle risk periods for obesity and how associations vary across race/ethnicity.
objectiveThe objective of this study was to examine joint associations of adiposity-related single-nucleotide polymorphisms (SNPs) and moderate to vigorous physical activity (MVPA) with body mass index (BMI) in a diverse adolescent cohort.
methodsUsing data from the National Longitudinal Study of Adolescent Health (n = 8113: Wave II 1996; ages 12-21, Wave III; ages 18-27), we assessed interactions of 41 well-established SNPs and MVPA with BMI-for-age Z-scores in European Americans (EA; n = 5077), African-Americans (AA; n = 1736) and Hispanic Americans (HA; n = 1300).
resultsOf 97 assessed, we found nominally significant SNP-MVPA interactions on BMI-for-age Z-score in EA at GNPDA2 and FTO and in HA at LZTR2/SEC16B. In EA, the estimated effect of the FTO risk allele on BMI-for-age Z-score was lower (β = -0.13; 95% confidence interval [CI]: 0.08, 0.18) in individuals with ≥5 vs. <5 (β = 0.24; CI: 0.16, 0.32) bouts of MVPA per week (P for interaction 0.02). Race/ethnicity-pooled meta-analysis showed nominally significant interactions for SNPs at TFAP2B, POC5 and LYPLAL1.
conclusionsHigh MVPA may attenuate underlying genetic risk for obesity during adolescence, a high-risk period for adult obesity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.