Evidence map›Paper›PMID 23529951›Full record

ReviewNMR in biomedicine2014

High-resolution magic angle spinning 1H MRS in prostate cancer.

Emily A Decelle, Leo L Cheng

Abstract readReview
In one paragraph

Review in NMR in biomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Characterization of Brain Metabolism by Nuclear Magnetic Resonance.Chemphyschem : a European journal of chemical physics and physical chemistry · 2019
    Review
  7. Article
  8. NMR-based metabolomics studies of human prostate cancer tissue.Metabolomics : Official journal of the Metabolomic Society · 2018
    Review
  9. Article
  10. Article
  11. Article
  12. MRS-based Metabolomics in Cancer Research.Magnetic resonance insights · 2014
    Review
  13. Potential of nuclear magnetic resonance metabolomics in the study of prostate cancer.Indian journal of urology : IJU : journal of the Urological Society of India
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Emily A DecelleDepartments of Pathology and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Leo L Cheng
Harvard University · US

Funding

Characterizing Prostate Cancer By ex vivo MRS SignaturesR01CA115746 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHENG, LEO L · 2006 to 2017
$6.4M
Detection of Lung Cancer Risks for Serum MetabolomicsR21CA141139 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHENG, LEO L · 2010 to 2011
$432k
Development of Metabolomic and Molecular Probes for Prostate Cancer AssessmentR21CA162959 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHENG, LEO L · 2011 to 2012
$418k
NCI NIH HHS CA115746NCI NIH HHS CA115746S2NCI NIH HHS CA141139NCI NIH HHS CA162959NCI NIH HHS R01 CA115746NCI NIH HHS R21 CA141139NCI NIH HHS R21 CA162959
6 · The paper itself

Abstract

Prostate cancer (PCa) is the most frequently diagnosed malignancy in men worldwide, largely as a result of the increased use of the annual serum prostate-specific antigen (PSA) screening test for detection. PSA screening has saved lives, but it has also resulted in the overtreatment of many patients with PCa because of a limited ability to accurately localize and characterize PCa lesions through imaging. High-resolution magic angle spinning (HRMAS) (1)H MRS has proven to be a strong potential clinical tool for PCa diagnosis and prognosis. The HRMAS technique allows valuable metabolic information to be obtained from ex vivo intact tissue samples and also enables the performance of histopathology on the same tissue specimens. Studies have found that the quantification of individual metabolite levels and metabolite ratios, as well as metabolomic profiles, shows strong potential to improve accuracy in PCa detection, diagnosis and monitoring. Ex vivo HRMAS is also a valuable tool for the interpretation of in vivo results, including the localization of tumors, and thus has the potential to improve in vivo diagnostic tests used in the clinic. Here, we primarily review publications of HRMAS (1)H MRS and its use for the study of intact human prostate tissue.

Indexed as

Magnetic Resonance SpectroscopyProtonsHumansMaleMetabolomeMetabolomicsProstateProstatic NeoplasmsProtonshigh-resolution magic angle spinning (HRMAS)intact tissueMRSprostate cancer

Identifiers

PMID23529951
PMCPMC3797175
OpenAlexW1796626740

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.