ArticleMolecular neurobiology2013
Gestational hypoxia induces sex-differential methylation of Crhr1 linked to anxiety-like behavior.
Article in Molecular neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Variations of Corticotropin-Releasing Factor Receptor 1α Contribute to the Blunted HPA Axis Responses to Hypoxia in Plateau Mammals.Neuroscience bulletin · 2026Article
- A Novel Relationship between Corticotropin-Releasing Hormone Level and High-Altitude Hypoxia in Human and Rat Model.Neuroendocrinology · 2026Article
- Perinatal omega-3 sex-selectively mitigates neuropsychiatric impacts of prenatal THC in the cortico-striatal-hippocampal circuit.Molecular psychiatry · 2025Article
- Nocturnal hypoxia moderates the relationship between rapid eye movement sleep and anxiety.BMC psychiatry · 2025Article
- Review
- miR-377-3p Regulates Hippocampal Neurogenesis via the Zfp462-Pbx1 Pathway and Mediates Anxiety-Like Behaviors in Prenatal Hypoxic Offspring.Molecular neurobiology · 2024Article
- The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review.eNeuro · 2023Review
- The mediating role of transmembrane protein 132D methylation in predicting the occurrence of panic disorder in physical abuse.Frontiers in psychiatry · 2022Article
- Early-life maternal deprivation affects the mother-offspring relationship in domestic pigs, as well as the neuroendocrine development and coping behavior of piglets.Frontiers in behavioral neuroscience · 2022Article
- CRHR1 mediates the transcriptional expression of pituitary hormones and their receptors under hypoxia.Frontiers in endocrinology · 2022Article
- Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats.Molecular neurobiology · 2021Article
- Effects of Prenatal Hypoxia on Nervous System Development and Related Diseases.Frontiers in neuroscience · 2021Review
- Mechanisms of Shared Vulnerability to Post-traumatic Stress Disorder and Substance Use Disorders.Frontiers in behavioral neuroscience · 2020Review
- Gestational Hypoxia and Developmental Plasticity.Physiological reviews · 2018Review
- Role of Prenatal Hypoxia in Brain Development, Cognitive Functions, and Neurodegeneration.Frontiers in neuroscience · 2018Review
- miR-34b attenuates trauma-induced anxiety-like behavior by targeting CRHR1.International journal of molecular medicine · 2017Article
- Modulation of the Hypothalamic-Pituitary-Adrenal Axis by Early Life Stress Exposure.Frontiers in cellular neuroscience · 2017Review
- Reduced CRHR-2 in placental tissues is associated with the high DNA methylation of CRHR-2 promoter in idiopathic preterm birth.International journal of clinical and experimental pathology · 2017Article
- Preconception Alcohol Increases Offspring Vulnerability to Stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Maternal stress and diet may influence affective behavior and stress-response in offspring via epigenetic regulation of central peptidergic function.Environmental epigenetics · 2016Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress during gestation increases vulnerability to disease and changes behavior in offspring. We previously reported that hypoxia and restraint during pregnancy sensitized the hypothalamic-pituitary-adrenal (HPA) axis and induced anxiety-like behavior in the adult offspring. Here, we report that gestational intermittent hypoxia (GIH) elicited a sex-dependent anxiety-like behavior in male P90 offspring and activation of corticotropin-releasing hormone (CRH) and CRH type-1 receptor (CRHR1) mRNA in the hypothalamic paraventricular nucleus (PVN) and in male E19 hypothalamus. These linked to demethylation at several specific sites of CpG island of Crhr1 promoter in P90 PVN and E19 embryo hypothalamus in GIH groups. Crhr1 DNA demethylation is more crucial in CpG island 1 than island 2 for activation of CRHR1 mRNA. DNMT3b is required for the Crhr1 DNA methylation than DNMT1 and DNMT3a in increased CRHR1 mRNA. We first address a novel hypothesis that GIH-induced male-sex-dependent demethylation at CpG sites of Crhr1 DNA in promoter triggers elevation of CRHR1 mRNA in PVN and anxiety-like behavior in adult offspring.
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