ArticleImmunogenetics2013
Diversity and evolution of the highly polymorphic tandem repeat LEI0258 in the chicken MHC-B region.
Article in Immunogenetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- The immune response modulated by inoculation of commensal bacteria at birth impacts the gut microbiota and preventsGut microbes · 2025Article
- Genetic insights into the major histocompatibility complex class I BF2 gene of Korean native chickens in relation to the LEI0258 microsatellite marker and the 90-SNP panel.Immunogenetics · 2025Article
- Evolutionary pressures rendered by animal husbandry practices for avian influenza viruses to adapt to humans.iScience · 2022Review
- Assessment of trade-offs between feed efficiency, growth-related traits, and immune activity in experimental lines of layer chickens.Genetics, selection, evolution : GSE · 2021Article
- High Levels of Genetic Variation in MHC-Linked Microsatellite Markers from Native Chicken Breeds.Genes · 2021Article
- Major histocompatibility complex B variability in Korean native chicken breeds.Poultry science · 2020Article
- Genetic diversity of MHC-B in 12 chicken populations in Korea revealed by single-nucleotide polymorphisms.Immunogenetics · 2020Article
- Advances in methodologies for detecting MHC-B variability in chickens.Poultry science · 2020Review
- Genetic diversity at major histocompatibility complex and its effect on production and immune traits in indigenous chicken breeds of India.Archives animal breeding · 2020Article
- Association of LEI0258 Marker Alleles and Susceptibility to Virulent Newcastle Disease Virus Infection in Kuroiler, Sasso, and Local Tanzanian Chicken Embryos.Journal of pathogens · 2020Article
- Genetic diversity of 10 indigenous chicken ecotypes from Southern Highlands of Tanzania based on Major Histocompatibility Complex-linked microsatellite LEI0258 marker typing.Poultry science · 2019Article
- A high-density SNP panel reveals extensive diversity, frequent recombination and multiple recombination hotspots within the chicken major histocompatibility complex B region between BG2 and CD1A1.Genetics, selection, evolution : GSE · 2016Article
Corrections and comments
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Authors and funding
14 authors at 11 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The chicken major histocompatibility complex (MHC) is located on the microchromosome 16 and is described as the most variable region in the genome. The genes of the MHC play a central role in the immune system. Particularly, genes encoding proteins involved in the antigen presentation to T cells. Therefore, describing the genetic polymorphism of this region is crucial in understanding host-pathogen interactions. The tandem repeat LEI0258 is located within the core area of the B region of the chicken MHC (MHC-B region) and its genotypes correlate with serology. This marker was used to provide a picture of the worldwide diversity of the chicken MHC-B region and to categorize chicken MHC haplotypes. More than 1,600 animals from 80 different populations or lines of chickens from Africa, Asia, and Europe, including wild fowl species, were genotyped at the LEI0258 locus. Fifty novel alleles were described after sequencing. The resulting 79 alleles were classified into 12 clusters, based on the SNPs and indels found within the sequences flanking the repeats. Furthermore, hypotheses were formulated on the evolutionary dynamics of the region. This study constitutes the largest variability report for the chicken MHC and establishes a framework for future diversity or association studies.
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