ArticleAmerican journal of Alzheimer's disease and other dementias2013
Involvement of heat shock protein 70 in the DNA protective effect from estrogen.
Article in American journal of Alzheimer's disease and other dementias, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 5 citations in OpenAlex.
- Impact of haemorrhagic shock intensity on the dynamic of alarmins release in porcine poly-trauma animal model.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2016Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As an endogenous cytoprotective factor, the protection of estrogen and heat shock protein-70 (Hsp70) on DNA has been documented, respectively, but the functional interaction between estrogen and Hsp70 on DNA damage repair is largely unknown. We therefore investigated the relation between estrogen and Hsp70 in terms of DNA protection in in vitro. The findings showed a significant reduction in cell survival and elevation in oxidative stress while cells were exposed to amyloid β (Aβ25-35) peptide, but preincubation of the cells with 17β-estradiol (17β-E2) ameliorated this situation. In addition, 17β-E2 alleviated oxidized DNA damage induced by Aβ and elevated the expression of Hsp70. However, the beneficial properties of 17β-E2 on reducing DNA damage were attenuated when Hsp70 gene was silenced accordingly. These results indicate that Hsp70 plays a role in DNA protection mediated by estrogen, and the DNA protection may be involved in Alzheimer's disease preventive effect from estrogen.
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