Evidence map›Paper›PMID 23528855›Full record

ArticleInternational journal of molecular sciences2013

Understanding resolvin signaling pathways to improve oral health.

David Keinan, Noel J Leigh, Joel W Nelson, Laura De Oleo, Olga J Baker

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

David KeinanDepartment of Periodontics and Endodontics, School of Dental Medicine, University at Buffalo, the State University of New York, Buffalo, NY 14214-3932, USA. olgabake@buffalo.edu.
Noel J Leigh
Joel W Nelson
Laura De Oleo
Olga J Baker

Funding

THE USE OF FIBRIN HYDROGELS TO PROMOTE SALIVARY GLAND REGENERATIONR01DE022971 · NIDCR · UNIVERSITY OF UTAH · PI ANDREADIS, STELIOS T., BAKER, OLGA JULIANA · 2012 to 2025
$7.2M
Resolution of Cytokine-Mediated Salivary Gland InflammationR01DE021697 · NIDCR · UNIVERSITY OF UTAH · PI BAKER, OLGA JULIANA · 2012 to 2016
$2.3M
Effect of SS-associated cytokines on salivary gland dysfunctionR21DE019721 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BAKER, OLGA JULIANA · 2010 to 2011
$418k
NIDCR NIH HHS R01 DE021697NIDCR NIH HHS R01 DE022971NIDCR NIH HHS R21 DE019721
6 · The paper itself

Abstract

The discovery of resolvins has been a major breakthrough for understanding the processes involved in resolution of inflammation. Resolvins belong to a family of novel lipid mediators that possess dual anti-inflammatory and pro-resolution actions. Specifically, they protect healthy tissue during immune-inflammatory responses to infection or injury, thereby aiding inflammation resolution and promoting tissue healing. One of the major concerns in modern medicine is the management and treatment of oral diseases, as they are related to systemic outcomes impacting the quality of life of many patients. This review summarizes known signaling pathways utilized by resolvins to regulate inflammatory responses associated with the oral cavity.

Identifiers

PMID23528855
PMCPMC3634469

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.