ReviewBiochimica et biophysica acta2013
A canine model of human aging and Alzheimer's disease.
Review in Biochimica et biophysica acta, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 150 citations in OpenAlex.
- Neurodegenerative diseases and immune system: From pathogenic mechanism to therapy.Neural regeneration research · 2026Article
- A canine brain bank for comparative neuroscience and brain aging research.bioRxiv : the preprint server for biology · 2026Article
- A Question of Origins: Non-neuronal Sources of Amyloid-β.Neuroscience bulletin · 2026Review
- Canine Cognitive Dysfunction from the Perspective of Dog Owners: Recognition, Care, and Emotional Challenges.Animals : an open access journal from MDPI · 2026Article
- Evidence-Based Clinical Management of Canine Cognitive Dysfunction Syndrome: Diagnostic Algorithms, Practical Guidelines, Critical Appraisal of Biomarkers and Translational Limitations.Animals : an open access journal from MDPI · 2026Review
- Canine Cognitive Dysfunction and Alzheimer's Disease: Pathophysiological Relationships and the Impact of Glymphatic System Impairment on Neurodegeneration.Veterinary sciences · 2026Review
- Functional assessments of short-term spatial memory in the Dog Aging Project identify strong associations with age that are not moderated by body mass.GeroScience · 2026Article
- Cerebral iron deposition in the Globus pallidus and Substantia nigra of aging dogs and cats presenting as bilateral hypointensity on T2w and iron-sensitive MRI sequences (SWI, T2*).Frontiers in veterinary science · 2026Article
- Untargeted plasma metabolomics in canine cognitive dysfunction: the naturally occurring Alzheimer's disease analog in dogs.Frontiers in neuroscience · 2026Article
- Alzheimer's disease neuropathological characterization of the dog brain and relationship to biofluid biomarkers and cognitive function.NPJ dementia · 2026Article
- GWAS for behavioral traits in golden retrievers identifies genes implicated in human temperament, mental health, and cognition.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Quantifying placebo and trial participation effects on cognitive outcome measures in aging dogs.GeroScience · 2025Article
- Longer duration of intact hypothalamic-pituitary-gonadal (HPG) axis buffers the adverse impact of late-life frailty in male dogs.Scientific reports · 2025Article
- Plasma and cerebrospinal fluid biomarkers in aged dogs with cognitive decline.BMC veterinary research · 2025Article
- Functional assessments of short-term spatial memory in the Dog Aging Project identify strong associations with age that are not moderated by body mass.bioRxiv : the preprint server for biology · 2025Article
- Serum TNF-Alpha and IL-10 Predict Reduced Sensitivity to Fear- and Anxiety-Related Traits in Healthy Older Dogs: Preliminary Evidence for Immune-Personality Signatures in Later Life.Animals : an open access journal from MDPI · 2025Article
- Applying a life course approach to elucidate the biology of sex differences in frailty: early-life gonadectomy diminishes late-life robustness in male and female dogs in the Exceptional Aging in Rottweilers Study.Biology of sex differences · 2025Article
- Article
- Krüppel-like factor 4 transcription factor in blood-brain barrier endothelial cells: A potential role in Alzheimer's disease.Animal models and experimental medicine · 2025Review
- Calcineurin inhibition may prevent Alzheimer disease in people with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The aged dog naturally develops cognitive decline in many different domains (including learning and memory) but also exhibits human-like individual variability in the aging process. The neurobiological basis for cognitive dysfunction may be related to structural changes that reflect neurodegeneration. Molecular cascades that contribute to degeneration in the aging dog brain include the progressive accumulation of beta-amyloid (Aβ) in diffuse plaques and in the cerebral vasculature. In addition, neuronal dysfunction occurs as a consequence of mitochondrial dysfunction and cumulative oxidative damage. In combination, the aged dog captures key features of human aging, making them particularly useful for the development of preventive or therapeutic interventions to improve aged brain function. These interventions can then be translated into human clinical trials. This article is part of a Special Issue entitled: Animal Models of Disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.