ArticleThe Journal of pharmacology and experimental therapeutics2013
Reversal of morphine analgesic tolerance by ethanol in the mouse.
Article in The Journal of pharmacology and experimental therapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Prevalence and Characteristics of Alcohol Use in Substance-Involved Deaths in St. Louis, Missouri, From 2011 to 2022.Journal of studies on alcohol and drugs · 2025Article
- Role of Acetaldehyde in Ethanol Reversal of Tolerance to Morphine-Induced Respiratory Depression in Mice.Advances in drug and alcohol research · 2022Article
- Mechanisms of Botulinum Toxin Type A Action on Pain.Toxins · 2019Review
- Oxycodone-induced tolerance to respiratory depression: reversal by ethanol, pregabalin and protein kinase C inhibition.British journal of pharmacology · 2018Article
- Ethanol Reversal of Oxycodone Tolerance in Dorsal Root Ganglia Neurons.Molecular pharmacology · 2018Article
- Reversal of oxycodone and hydrocodone tolerance by diazepam.Brain research · 2017Article
- Ethanol Reversal of Tolerance to the Antinociceptive Effects of Oxycodone and Hydrocodone.The Journal of pharmacology and experimental therapeutics · 2017Article
- Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse liability in rodents.Journal of psychopharmacology (Oxford, England) · 2017Article
- Opioids Resistance in Chronic Pain Management.Current neuropharmacology · 2017Review
- Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.Pharmacological reviews · 2016Review
- Ethanol Reversal of Tolerance to the Respiratory Depressant Effects of Morphine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Varenicline decreases nicotine but not alcohol self-administration in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats.Drug and alcohol dependence · 2015Article
- The μ-opioid receptor: an electrophysiologist's perspective from the sharp end.British journal of pharmacology · 2015Review
- Ethanol reversal of cellular tolerance to morphine in rat locus coeruleus neurons.Molecular pharmacology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The chronic use of opioids in humans, accompanied by the development of tolerance, is a dangerous phenomenon in its own right. However, chronic opioid use is often made more dangerous by the coconsumption of other substances. It has been observed that the blood level of opioids in postmortem analyses of addicts, who consumed ethanol along with the opioid, was much less than that observed in individuals who died from opioids alone. This relationship between ethanol and opioids led us to investigate the hypothesis that ethanol alters tolerance to opioids. In the present study, we report that ethanol significantly and dose-dependently reduced the antinociceptive tolerance produced by morphine and the cross-tolerance between [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO) and morphine in the mouse tail-flick test. The reversal of morphine tolerance was partially blocked by both the gamma receptor blocker bicuculline and by the γ-aminobutyric acid (GABA)(B) receptor blocker phaclofen and the administration of both inhibitors completely reversed the effects of ethanol on morphine tolerance. Diazepam, like ethanol, decreased morphine tolerance. However, this inhibition was reversed by the GABA(A) antagonist bicuculline but not by the GABA(B) antagonist phaclofen. These findings have important implications for individuals who abuse opioids and ethanol as well as suggest a mechanism to reduce the amount of opioid needed in chronic pain treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.