Trial reportDrug and alcohol dependence2013
Association of cannabis use with opioid outcomes among opioid-dependent youth.
Trial report in Drug and alcohol dependence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Cannabinoid exposure across substance use disorders: Short-term symptom benefits without sustained therapeutic gains in a tier-weighted systematic review.European psychiatry : the journal of the Association of European Psychiatrists · 2026Pooled it
- Buprenorphine for managing opioid withdrawal.The Cochrane database of systematic reviews · 2017Pooled it
- Maintenance treatments for opiate -dependent adolescents.The Cochrane database of systematic reviews · 2014Pooled it
- Detoxification treatments for opiate dependent adolescents.The Cochrane database of systematic reviews · 2014Pooled it
- Effects of randomization to buprenorphine or naltrexone for OUD on cannabis use outcomes: A secondary analysis of the X:BOT trial.Drug and alcohol dependence · 2025Trial
- Marijuana use and achievement of abstinence from alcohol and other drugs among people with substance dependence: a prospective cohort study.Drug and alcohol dependence · 2014Trial
- Variations of cannabis-related adverse mental health and addiction outcomes across adolescence and adulthood: A scoping review.Frontiers in psychiatry · 2022Article
- Green Hope: Perspectives on Cannabis from People who Use Opioids.Sociological inquiry · 2021Article
- The association between cannabis use and outcome in pharmacological treatment for opioid use disorder.Harm reduction journal · 2021Article
- Smoking heroin with cannabis versus injecting heroin: unexpected impact on treatment outcomes.Harm reduction journal · 2019Article
- High-intensity cannabis use is associated with retention in opioid agonist treatment: a longitudinal analysis.Addiction (Abingdon, England) · 2018Article
- Medicinal versus Recreational Cannabis Use among Returning Veterans.Translational issues in psychological science · 2018Article
- Non-medical Cannabis Self-Exposure as a Dimensional Predictor of Opioid Dependence Diagnosis: A Propensity Score Matched Analysis.Frontiers in psychiatry · 2018Article
- Impact of Cannabis Use on Treatment Outcomes among Adults Receiving Cognitive-Behavioral Treatment for PTSD and Substance Use Disorders.Journal of clinical medicine · 2017Article
- The impact of cannabis use on patients enrolled in opioid agonist therapy in Ontario, Canada.PloS one · 2017Article
- Association between cannabis use and treatment outcomes in patients receiving methadone maintenance treatment: a systematic review protocol.Systematic reviews · 2016Article
- Buprenorphine Treatment for Adolescents and Young Adults With Opioid Use Disorders: A Narrative Review.Journal of addiction medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveCannabis use is common among opioid-dependent patients, but studies of its association with treatment outcome are mixed. In this secondary analysis, the association of cannabis use with opioid treatment outcome is assessed.
methodsIn the main study, participants (n=152) aged 15-21 years were randomized to receive psychosocial treatments and either a 12-week course of buprenorphine-naloxone with a dose taper to zero in weeks 9-12, or a 2-week detoxification with buprenorphine-naloxone. Drug use was assessed by self-report and urine drug screen at baseline and during study weeks 1-12. The association between cannabis and opioid use at weeks 4, 8, and 12 was examined using logistic regression models.
resultsParticipants reported a median of 3.0 days (range=0-30) cannabis use in the past month; half (50.3%; n=77) reported occasional use, one-third reported no use (33.1%; n=50), and one-sixth reported daily cannabis use (16.6%; n=25). Median lifetime cannabis use was 4.0 years (range=0-11) and median age of initiation of use was 15.0 years (range 9-21). Neither past cannabis use (age of initiation and use in the month prior to baseline) nor concurrent use was associated with level of opioid use.
conclusionsOverall, cannabis use had no association with opioid use over 12 weeks in this sample of opioid-dependent youth. While cannabis use remains potentially harmful, it was not a predictor of poor opioid treatment outcome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.