ArticleHearing research2013
A null mutation of mouse Kcna10 causes significant vestibular and mild hearing dysfunction.
Article in Hearing research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Multi-omics analysis of ion channels expressed by chicken embryo vestibular type I and type II hair cells.Experimental physiology · 2026Article
- Early downregulation of hair cell (HC)-specific genes in the vestibular sensory epithelium during chronic ototoxicity.Journal of biomedical science · 2025Article
- Optimized inner ear organoids for efficient hair cell generation and ototoxicity response modeling.Science China. Life sciences · 2025Article
- KbioRxiv : the preprint server for biology · 2025Article
- Evolutionary analysis of genes associated with the sense of balance in semi-aquatic mammals.BMC ecology and evolution · 2025Article
- The potassium channel subunit KeLife · 2024Article
- The role of ATP-binding Cassette subfamily B member 6 in the inner ear.Nature communications · 2024Article
- Review
- The potassium channel subunit KbioRxiv : the preprint server for biology · 2024Article
- Mapping the developmental potential of mouse inner ear organoids at single-cell resolution.iScience · 2024Article
- Electrophysiological properties of vestibular hair cells isolated from human crista.Frontiers in neurology · 2024Article
- Article
- Spontaneous mutations of the Zpld1 gene in mice cause semicircular canal dysfunction but do not impair gravity receptor or hearing functions.Scientific reports · 2019Article
- Effect of M-current modulation on mammalian vestibular responses to transient head motion.Journal of neurophysiology · 2017Article
- Rescue of peripheral vestibular function in Usher syndrome mice using a splice-switching antisense oligonucleotide.Human molecular genetics · 2017Article
- Electrophysiological Measurements of Peripheral Vestibular Function-A Review of Electrovestibulography.Frontiers in systems neuroscience · 2017Review
- Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice.Journal of the Association for Research in Otolaryngology : JARO · 2016Article
- Differential effects of Cdh23(753A) on auditory and vestibular functional aging in C57BL/6J mice.Neurobiology of aging · 2016Article
- Exploring regulatory networks of miR-96 in the developing inner ear.Scientific reports · 2016Article
- A comprehensive catalogue of the coding and non-coding transcripts of the human inner ear.Hearing research · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
KCNA10 is a voltage gated potassium channel that is expressed in the inner ear. The localization and function of KCNA10 was studied in a mutant mouse, B6-Kcna10(TM45), in which the single protein coding exon of Kcna10 was replaced with a beta-galactosidase reporter cassette. Under the regulatory control of the endogenous Kcna10 promoter and enhancers, beta-galactosidase was expressed in hair cells of the vestibular organs and the organ of Corti. KCNA10 expression develops in opposite tonotopic gradients in the inner and outer hair cells. Kcna10(TM45) homozygotes display only a mild elevation in pure tone hearing thresholds as measured by auditory brainstem response (ABR), while heterozygotes are normal. However, Kcna10(TM45) homozygotes have absent vestibular evoked potentials (VsEPs) or elevated VsEP thresholds with prolonged peak latencies, indicating significant vestibular dysfunction despite the lack of any overt imbalance behaviors. Our results suggest that Kcna10 is expressed primarily in hair cells of the inner ear, with little evidence of expression in other organs. The Kcna10(TM45) targeted allele may be a model of human nonsyndromic vestibulopathy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.