Evidence map›Paper›PMID 23528268›Full record

ArticleCurrent opinion in neurobiology2013

Identifying the molecular basis of inhibitory control deficits in addictions: neuroimaging in non-human primates.

Stephanie M Groman, J David Jentsch

Open access · greenAbstract read
In one paragraph

Article in Current opinion in neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Dissecting impulsivity and its relationships to drug addictions.Annals of the New York Academy of Sciences · 2014
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Stephanie M GromanDepartment of Psychology, University of California, Los Angeles, United States.
J David Jentsch
University of California, Los Angeles · US

Funding

UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
NEUROCHEMISTRY OF MODAFINIL-MA INTERACTION IN RAT BRAINP20DA022539 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE DANICK · 2006 to 2009
$2.9M
Genetic Influences on Inhibitory Control and Cocaine SensitivityR01DA031852 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JENTSCH, J. DAVID · 2012 to 2016
$1.7M
Impulsivity and D2 Receptor Function: Behavioral and PET CorrelatesF31DA028812 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GROMAN, STEPHANIE MARY · 2010 to 2012
$100k
NIDA NIH HHS F31 DA028812NIDA NIH HHS F31-DA028812NIDA NIH HHS P20 DA022539NIDA NIH HHS R01 DA031852NIDA NIH HHS R01-DA031852NIDA NIH HHS T32 DA024635NIDA NIH HHS T32-DA024635
6 · The paper itself

Abstract

Deep insights into the structural, molecular and functional phenotypes underlying addiction have been made possible through in vivo neuroimaging techniques implemented in non-human and human primates. In addition to providing evidence that many of the neural alterations detected in stimulant-dependent individuals can emerge solely through experience with drugs, these studies have identified potential biological phenotypes that influence addiction liability. Here, we review recent advances that have been made in understanding the pathophysiology of stimulant addiction using neuroimaging techniques in non-human primates. Evidence indicates that dysfunction of the dopamine system can be both a cause and consequence of stimulant use and that this bi-directional relationship may be mediated by the ability of individuals to exert inhibitory control over behaviors. Further, recent data has demonstrated an involvement of the serotonin system in addiction-related behaviors and neurobiology, suggesting that the relationship between dopamine and serotonin systems may be altered in addiction. This approach aids in the development of novel targets that can be used in the treatment of addiction.

Indexed as

Behavior, AddictiveInhibition, PsychologicalNeuroimagingAnimalsDopamineHumansSubstance-Related DisordersDopamine

Identifiers

PMID23528268
PMCPMC3731407
OpenAlexW1980578430

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.