Evidence map›Paper›PMID 23528237›Full record

ReviewCurrent opinion in biotechnology2013

Molecular tools for chemical biotechnology.

Stephanie Galanie, Michael S Siddiqui, Christina D Smolke

Abstract readReview
In one paragraph

Review in Current opinion in biotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Photocleavable Guide crRNAs for a Light-Controllable CRISPR/Cas9 System.International journal of molecular sciences · 2024
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stephanie GalanieDepartment of Chemistry, Stanford University, Stanford, CA 94305, United States; Department of Bioengineering, Stanford University, 473 Via Ortega, MC 4201, Stanford, CA 94305, United States.
Michael S Siddiqui
Christina D Smolke

Funding

Synthetic Biology Platforms for Natural Product Discovery and BiosynthesisDP1AT007886 · NCCIH · STANFORD UNIVERSITY · PI SMOLKE, CHRISTINA D · 2012 to 2016
$3.9M
Frameworks for programming ligand-responsive RNA regulatory systemsR01GM086663 · NIGMS · STANFORD UNIVERSITY · PI ENDY, DREW · 2009 to 2024
$3.7M
NCCIH NIH HHS DP1 AT007886NIGMS NIH HHS R01 GM086663
6 · The paper itself

Abstract

Biotechnological production of high value chemical products increasingly involves engineering in vivo multi-enzyme pathways and host metabolism. Recent approaches to these engineering objectives have made use of molecular tools to advance de novo pathway identification, tunable enzyme expression, and rapid pathway construction. Molecular tools also enable optimization of single enzymes and entire genomes through diversity generation and screening, whole cell analytics, and synthetic metabolic control networks. In this review, we focus on advanced molecular tools and their applications to engineered pathways in host organisms, highlighting the degree to which each tool is generalizable.

Indexed as

Biosynthetic PathwaysBiotechnologyMetabolic EngineeringSystems Biology

Identifiers

PMID23528237
PMCPMC3740197

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.