ArticleBiophysical journal2013
Frequency-dependent properties of the tectorial membrane facilitate energy transmission and amplification in the cochlea.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Critical role of hepsin/TMPRSS1 in hearing and tectorial membrane morphogenesis: Insights from transgenic mouse models.Hearing research · 2024Article
- Local cochlear mechanical responses revealed through outer hair cell receptor potential measurements.Biophysical journal · 2024Article
- Age-related degradation of tectorial membrane dynamics with loss of CEACAM16.Biophysical journal · 2021Article
- The Tectorial Membrane: Mechanical Properties and Functions.Cold Spring Harbor perspectives in medicine · 2019Review
- Reducing tectorial membrane viscoelasticity enhances spontaneous otoacoustic emissions and compromises the detection of low level sound.Scientific reports · 2019Article
- Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography.Quantitative imaging in medicine and surgery · 2019Review
- Anisotropic Material Properties of Wild-Type and TectbBiophysical journal · 2019Article
- Nanoscale Poroelasticity of the Tectorial Membrane Determines Hair Bundle Deflections.Physical review letters · 2019Article
- Drug Diffusion Along an Intact Mammalian Cochlea.Frontiers in cellular neuroscience · 2019Article
- The Competition between the Noise and Shear Motion Sensitivity of Cochlear Inner Hair Cell Stereocilia.Biophysical journal · 2018Article
- Geometric Requirements for Tectorial Membrane Traveling Waves in the Presence of Cochlear Loads.Biophysical journal · 2017Article
- A connexin30 mutation rescues hearing and reveals roles for gap junctions in cochlear amplification and micromechanics.Nature communications · 2017Article
- Longitudinal spread of mechanical excitation through tectorial membrane traveling waves.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Power dissipation in the subtectorial space of the mammalian cochlea is modulated by inner hair cell stereocilia.Biophysical journal · 2015Article
- Modified protein expression in the tectorial membrane of the cochlea reveals roles for the striated sheet matrix.Biophysical journal · 2015Article
- Basilar membrane and tectorial membrane stiffness in the CBA/CaJ mouse.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Porosity controls spread of excitation in tectorial membrane traveling waves.Biophysical journal · 2014Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The remarkable sensitivity, frequency selectivity, and dynamic range of the mammalian cochlea relies on longitudinal transmission of minuscule amounts of energy as passive, pressure-driven, basilar membrane (BM) traveling waves. These waves are actively amplified at frequency-specific locations by a mechanism that involves interaction between the BM and another extracellular matrix, the tectorial membrane (TM). From mechanical measurements of isolated segments of the TM, we made the important new (to our knowledge) discovery that the stiffness of the TM is reduced when it is mechanically stimulated at physiologically relevant magnitudes and at frequencies below their frequency place in the cochlea. The reduction in stiffness functionally uncouples the TM from the organ of Corti, thereby minimizing energy losses during passive traveling-wave propagation. Stiffening and decreased viscosity of the TM at high stimulus frequencies can potentially facilitate active amplification, especially in the high-frequency, basal turn, where energy loss due to internal friction within the TM is less than in the apex. This prediction is confirmed by neural recordings from several frequency regions of the cochlea.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.