Evidence map›Paper›PMID 23527547›Full record

ReviewAnnual review of analytical chemistry (Palo Alto, Calif.)2013

Semiconductor quantum dots for bioimaging and biodiagnostic applications.

Brad A Kairdolf, Andrew M Smith, Todd H Stokes, May D Wang, Andrew N Young, Shuming Nie

Abstract readReview
In one paragraph

Review in Annual review of analytical chemistry (Palo Alto, Calif.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

134 citing papers in PubMed.

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74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brad A KairdolfDepartment of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA. snie@emory.edu
Andrew M Smith
Todd H Stokes
May D Wang
Andrew N Young
Shuming Nie

Funding

Tissue and Animal UseU54CA119338 · NCI · EMORY UNIVERSITY · PI WANG, DONGMEI · 2005 to 2009
$18.4M
Contrast-Enhanced and Image-Guided Surgery of Lung CancerR01CA163256 · NCI · EMORY UNIVERSITY · PI JO, HANJOONG, SINGHAL, SUNIL · 2011 to 2015
$6.5M
Nanotechnology for Multiplexed and Intraoperative Cancer DetectionRC2CA148265 · NCI · EMORY UNIVERSITY · PI NIE, SHUMING · 2009 to 2010
$2.0M
Next-Generation Quantum Dots for Molecular and Cellular Imaging of CancerR00CA153914 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SMITH, ANDREW MICHAEL · 2012 to 2014
$709k
Tumor Targeting and Diagnostic Applications of Glycosylated NanotubesK99CA154006 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SINGH, RAVI N · 2010 to 2011
$257k
NCI NIH HHS K99 CA154006NCI NIH HHS R00 CA153914NCI NIH HHS R01 CA163256NCI NIH HHS R01CA163256NCI NIH HHS RC2 CA148265NCI NIH HHS RC2CA148265NCI NIH HHS U54 CA119338NHLBI NIH HHS HHSN268201000043C
6 · The paper itself

Abstract

Semiconductor quantum dots (QDs) are light-emitting particles on the nanometer scale that have emerged as a new class of fluorescent labels for chemical analysis, molecular imaging, and biomedical diagnostics. Compared with traditional fluorescent probes, QDs have unique optical and electronic properties such as size-tunable light emission, narrow and symmetric emission spectra, and broad absorption spectra that enable the simultaneous excitation of multiple fluorescence colors. QDs are also considerably brighter and more resistant to photobleaching than are organic dyes and fluorescent proteins. These properties are well suited for dynamic imaging at the single-molecule level and for multiplexed biomedical diagnostics at ultrahigh sensitivity. Here, we discuss the fundamental properties of QDs; the development of next-generation QDs; and their applications in bioanalytical chemistry, dynamic cellular imaging, and medical diagnostics. For in vivo and clinical imaging, the potential toxicity of QDs remains a major concern. However, the toxic nature of cadmium-containing QDs is no longer a factor for in vitro diagnostics, so the use of multicolor QDs for molecular diagnostics and pathology is probably the most important and clinically relevant application for semiconductor QDs in the immediate future.

Indexed as

Quantum DotsSemiconductorsBiomarkers, TumorCadmium CompoundsDiagnostic ImagingDNAHumansImmunohistochemistryIn Situ Hybridization, FluorescenceMaleNanoparticlesNanotechnologyNeoplasmsPolyethylene GlycolsProstateSelenium CompoundsBiomarkers, TumorCadmium Compoundscadmium selenidecadmium tellurideDNAPolyethylene GlycolsSelenium CompoundsTellurium

Identifiers

PMID23527547
PMCPMC3733675

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.