ArticleUpsala journal of medical sciences2013
Dynamic changes in glycosylation and glycan composition of serum FSH and LH during natural ovarian stimulation.
Article in Upsala journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- Follicular development during the follicular phase of the menstrual cycle: the enigma of luteinizing hormone receptor function.Frontiers in endocrinology · 2026Article
- Development of a cAMP biosensor-based assay for measuring serum bioactive concentrations of FSH.PloS one · 2026Article
- Studying ovarian aging and its health impacts: modern tools and approaches.Genes & development · 2025Review
- RNA-seq analysis identifies age-dependent changes in expression of mRNAs - encoding N-glycosylation pathway enzymes in mouse gonadotropes.Molecular and cellular endocrinology · 2023Article
- Follicle-Stimulating Hormone Biological Products: Does Potency Predict Clinical Efficacy?International journal of molecular sciences · 2023Review
- Determination of Half-lives of Circulating FSH and LH Glycoforms in Women During GnRH Receptor Blockade.The Journal of clinical endocrinology and metabolism · 2022Article
- Reduced FSH and LH action: implications for medically assisted reproduction.Human reproduction (Oxford, England) · 2021Review
- Recent advances in understanding gonadotropin signaling.Faculty reviews · 2021Review
- New Human Follitropin Preparations: How Glycan Structural Differences May Affect Biochemical and Biological Function and Clinical Effect.Frontiers in endocrinology · 2021Review
- Gonadotropin Glycoforms Circulating in Women Using Progestins of the Levonorgestrel Family for Contraception.Journal of the Endocrine Society · 2020Article
- In Vitro Impact of FSH Glycosylation Variants on FSH Receptor-stimulated Signal Transduction and Functional Selectivity.Journal of the Endocrine Society · 2020Article
- FSH for the Treatment of Male Infertility.International journal of molecular sciences · 2020Review
- Discovery and Preclinical Development of Orally Active Small Molecules that Exhibit Highly Selective Follicle Stimulating Hormone Receptor Agonism.Frontiers in pharmacology · 2020Article
- Recombinant FSH glycoforms are bioactive in mouse preantral ovarian follicles.Reproduction (Cambridge, England) · 2019Article
- Follicle-Stimulating Hormone Glycobiology.Endocrinology · 2019Review
- Glycosylation Pattern andFrontiers in endocrinology · 2019Article
- Betaglycan (TGFBR3) Functions as an Inhibin A, but Not Inhibin B, Coreceptor in Pituitary Gonadotrope Cells in Mice.Endocrinology · 2018Article
- Low-glycosylated forms of both FSH and LH play major roles in the natural ovarian stimulation.Upsala journal of medical sciences · 2018Article
- Molecular regulation of follicle-stimulating hormone synthesis, secretion and action.Journal of molecular endocrinology · 2018Review
- Molecular size and charge as dimensions to identify and characterize circulating glycoforms of human FSH, LH and TSH.Upsala journal of medical sciences · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlycosylation and glycan composition are of fundamental importance for the biological properties of FSH and LH. The aim of this study was to determine the glycosylation, sialylation, and sulfonation of serum FSH and LH throughout the normal menstrual cycle.
methodsSerum samples were collected from 79 healthy women with regular menstrual cycles. The mean numbers of anionic monosaccharide (AMS), sialic acid (SA), and sulfonated N-acetylgalactosamine (SU) residues per FSH and LH molecule were estimated for all sera with methods based on electrophoreses, neuraminidase treatments, and fluoroimmunoassays of the gonadotrophins.
resultsDi-glycosylated glycoforms (FSHdi, LHdi) were detected in serum in addition to tetra-glycosylated FSH (FSHtetra) and tri-glycosylated LH (LHtri). FSHdi exhibited two peaks: one on day 5 to 7 and one, more pronounced, at midcycle. FSHtetra plateaued at a high concentration from day 5 to 15, without a midcycle peak. There were lower concentrations of LHdi than LHtri, except at midcycle when the opposite occurred. The mean numbers of SA and SU residues per molecule of FSH and LH in serum showed four different patterns during the cycle, all with highly significant (P < 0.0001) differences between levels at different phases of the cycle. The pattern of SA residues on FSH was 'M'-shaped, and that of SU on LH 'V'-shaped.
conclusionSerum FSH and LH governing the natural ovarian stimulation process exhibited dynamic changes of glycosylation and glycan composition. This new information on the FSH and LH molecular structures may lead to more successful mono-ovulatory treatment regimens for ovulation induction in anovulatory women.
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