ArticlePloS one2013
Oxidative status and lipofuscin accumulation in urothelial cells of bladder in aging mice.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- Polyploid superficial uroepithelial bladder barrier cells express features of cellular senescence across the lifespan and are insensitive to senolytics.Aging cell · 2025Article
- Mechanisms of oxidative stress in interstitial cystitis/bladder pain syndrome.Nature reviews. Urology · 2024Review
- D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder.Developmental cell · 2024Article
- Hallmarks and Biomarkers of Skin Senescence: An Updated Review of Skin Senotherapeutics.Antioxidants (Basel, Switzerland) · 2023Review
- Effects of aging on urinary tract epithelial homeostasis and immunity.Developmental biology · 2023Review
- Aging-Associated Changes in Oxidative Stress Negatively Impacts the Urinary Bladder Urothelium.International neurourology journal · 2022Article
- Modulation of Autophagy: A Novel "Rejuvenation" Strategy for the Aging Liver.Oxidative medicine and cellular longevity · 2021Review
- The Urothelium: Life in a Liquid Environment.Physiological reviews · 2020Review
- The Role of Autophagy for the Regeneration of the Aging Liver.International journal of molecular sciences · 2020Review
- Does the Urothelium of Old Mice Regenerate after Chitosan Injury as Quickly as the Urothelium of Young Mice?International journal of molecular sciences · 2020Article
- General, 21-Day Postoperative Rehabilitation Program Has Beneficial Effect on Oxidative Stress Markers in Patients after Total Hip or Knee Replacement.Oxidative medicine and cellular longevity · 2020Article
- Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells.Nature communications · 2019Article
- A newly characterized exopolysaccharide from Sanghuangporus sanghuang.Journal of microbiology (Seoul, Korea) · 2019Article
- Acute spinal cord injury is associated with mitochondrial dysfunction in mouse urothelium.Neurourology and urodynamics · 2019Article
- NLRP3/IL1β inflammasome associated with the aging bladder triggers bladder dysfunction in female rats.Molecular medicine reports · 2019Article
- The aging bladder insights from animal models.Asian journal of urology · 2018Review
- Association of benign prostatic hyperplasia and subsequent risk of bladder cancer: an Asian population cohort study.World journal of urology · 2018Article
- Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Urinary Incontinence in Older Adults: A Translational Research Agenda for a Complex Geriatric Syndrome.Journal of the American Geriatrics Society · 2018Review
- GPX2 promotes development of bladder cancer with squamous cell differentiation through the control of apoptosis.Oncotarget · 2018Article
- Age-related endolysosome dysfunction in the rat urothelium.PloS one · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related changes in various tissues have been associated with the onset of a number of age-related diseases, including inflammation and cancer. Bladder cancer, for instance, is a disease that mainly afflicts middle-aged or elderly people and is mostly of urothelial origin. Although research on age-related changes of long-lived post-mitotic cells such as neurons is rapidly progressing, nothing is known about age-related changes in the urothelium of the urinary bladder, despite all the evidence confirming the important role of oxidative stress in urinary bladder pathology. The purpose of this study was thus to investigate the oxidative status and age-related changes in urothelial cells of the urinary bladder of young (2 months) and aging (20 months) mice by means of various methods. Our results demonstrated that healthy young urothelium possesses a powerful antioxidant defence system that functions as a strong defence barrier against reactive species. In contrast, urothelial cells of aging bladder show significantly decreased total antioxidant capacity and significantly increased levels of lipid peroxides (MDA) and iNOS, markers of oxidative stress. Our study demonstrates for the first time that ultrastructural alterations in mitochondria and accumulation of lipofuscin, known to be one of the aging pigments, can clearly be found in superficial urothelial cells of the urinary bladder in aging mice. Since the presence of lipofuscin in the urothelium has not yet been reported, we applied various methods to confirm our finding. Our results reveal changes in the oxidative status and structural alterations to superficial urothelial cells similar to those of other long-lived post-mitotic cells.
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