ArticlePloS one2013
Environmental and genetic contribution to hypertension prevalence: data from an epidemiological survey on Sardinian genetic isolates.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Heritability of blood pressure traits in diverse populations: a systematic review and meta-analysis.Journal of human hypertension · 2019Pooled it
- E-selectin gene polymorphisms and essential hypertension in Asian population: an updated meta-analysis.PloS one · 2014Pooled it
- Sex differences in hypertension incidence and risk factors: a population-based cohort study in Southern Iran.BMC public health · 2024Article
- Association of hypertension with noodle consumption among Korean adults based on the Health Examinees (HEXA) study.Nutrition research and practice · 2024Article
- The Association of M235T Genetic Polymorphism inJournal of personalized medicine · 2024Article
- What causes concordance of hypertension between spouses in India? Identifying a critical knowledge gap from a nationally representative cross-sectional sample of 63,020 couples aged 15 + years.BMC public health · 2023Article
- The role of dietary salt in metabolism and energy balance: Insights beyond cardiovascular disease.Diabetes, obesity & metabolism · 2023Review
- Combating hypertension beyond genome-wide association studies: Microbiome and artificial intelligence as opportunities for precision medicine.Cambridge prisms. Precision medicine · 2023Review
- Determinants of self-reported hypertension among women in South Africa: evidence from the population-based survey.Clinical hypertension · 2022Article
- Exploratory study of the association in the United Kingdom between hypertension and inorganic arsenic (iAs) intake from rice and rice products.Environmental geochemistry and health · 2021Article
- A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease.International journal of molecular sciences · 2020Review
- Genetics of Human Primary Hypertension: Focus on Hormonal Mechanisms.Endocrine reviews · 2019Review
- Familial aggregation and heritability of hypertension in Han population in Shanghai China: a case-control study.Clinical hypertension · 2019Article
- Noncoding RNAs in Cardiovascular Disease: Pathological Relevance and Emerging Role as Biomarkers and Therapeutics.American journal of hypertension · 2018Review
- Blood Pressure Genetic Risk Score Predicts Blood Pressure Responses to Dietary Sodium and Potassium: The GenSalt Study (Genetic Epidemiology Network of Salt Sensitivity).Hypertension (Dallas, Tex. : 1979) · 2017Article
- Interactions of homocysteine and conventional predisposing factors on hypertension in Chinese adults.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
- Genetic Mechanisms Leading to Sex Differences Across Common Diseases and Anthropometric Traits.Genetics · 2017Article
- Interactions of Methylenetetrahydrofolate Reductase C677T Polymorphism with Environmental Factors on Hypertension Susceptibility.International journal of environmental research and public health · 2016Article
- Genetic Loci and Novel Discrimination Measures Associated with Blood Pressure Variation in African Americans Living in Tallahassee.PloS one · 2016Article
- Who is at higher risk of hypertension? Socioeconomic status differences in blood pressure among Polish adolescents: a population-based ADOPOLNOR study.European journal of pediatrics · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesHypertension represents a major cause of cardiovascular morbidity and mortality worldwide but its prevalence has been shown to vary in different countries. The reasons for such differences are still matter of debate, the relative contributions given by environmental and genetic factors being still poorly defined. We estimated the current prevalence, distribution and determinants of hypertension in isolated Sardinian populations and also investigated the environmental and genetic contribution to hypertension prevalence taking advantage of the characteristics of such populations. METHODS AND
resultsAn epidemiological survey with cross-sectional design was carried out measuring blood pressure in 9845 inhabitants of 10 villages of Ogliastra region between 2002 and 2008. Regression analysis for assessing blood pressure determinants and variance component models for estimating heritability were performed. Overall 38.8% of this population had hypertension, its prevalence varying significantly by age, sex and among villages taking into account age and sex structure of their population. About 50% of hypertensives had prior cardiovascular disease. High blood pressure was independently associated with age, obesity related factors, heart rate, total cholesterol, alcohol consumption, low education and smoking status, all these factors contributing more in women than in men. Heritability was 27% for diastolic and 36% for systolic blood pressure, its contribution being significantly higher in men (57%) than in women (46%). Finally, the genetic correlation between systolic and diastolic blood pressure was 0.74, indicating incomplete pleiotropy.
conclusionGenetic factors involved in the expression of blood pressure traits account for about 30% of the phenotypic variance, but seem to play a larger role in men; comorbidities and environmental factors remain of predominant importance, but seem to contribute much more in women.
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