ArticlePloS one2013
Changes of functional and effective connectivity in smoking replenishment on deprived heavy smokers: a resting-state FMRI study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Longitudinal changes in network engagement during cognitive control in cocaine use disorder.Drug and alcohol dependence · 2021Trial
- Short-term nicotine deprivation alters dorsal anterior cingulate glutamate concentration and concomitant cingulate-cortical functional connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Internet addiction and functional brain networks: task-related fMRI study.Scientific reports · 2019Trial
- Network localization of gray matter alterations in chronic smokers using the normative functional connectome.Frontiers in public health · 2026Article
- Smoking alters effective connectivity of resting-state brain networks in mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Article
- Abnormal resting-state effective connectivity of triple network predicts smoking motivations among males.Frontiers in psychiatry · 2025Article
- The effects of nicotine use during adolescence and young adulthood on gray matter cerebral blood flow estimates.Brain imaging and behavior · 2024Article
- Negative affect and craving during abstinence from smoking are both linked to default mode network connectivity.Drug and alcohol dependence · 2023Article
- Effects of Smoking Status and State on Intrinsic Connectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Article
- Effects of Cigarette Smoking on Resting-State Functional Connectivity of the Nucleus Basalis of Meynert in Mild Cognitive Impairment.Frontiers in aging neuroscience · 2021Article
- Schizophrenia EEG Signal Classification Based on Swarm Intelligence Computing.Computational intelligence and neuroscience · 2020Article
- The insula in nicotine use disorder: Functional neuroimaging and implications for neuromodulation.Neuroscience and biobehavioral reviews · 2019Review
- Multimodal neurocognitive markers of interoceptive tuning in smoked cocaine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Alterations in resting-state functional connectivity in substance use disorders and treatment implications.Progress in neuro-psychopharmacology & biological psychiatry · 2019Review
- Robust detection of event-related potentials in a user-voluntary short-term imagery task.PloS one · 2019Article
- Changes in resting state functional brain connectivity and withdrawal symptoms are associated with acute electronic cigarette use.Brain research bulletin · 2018Article
- [Research on the rest functional magnetic resonance imaging before and after smoking cessation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2018Article
- Resting State Functional Connectivity of the Lateral and Medial Hypothalamus in Cocaine Dependence: An Exploratory Study.Frontiers in psychiatry · 2018Article
- Brain Structure Alterations in Respect to Tobacco Consumption and Nicotine Dependence: A Comparative Voxel-Based Morphometry Study.Frontiers in neuroanatomy · 2018Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous researches have explored the changes of functional connectivity caused by smoking with the aid of fMRI. This study considers not only functional connectivity but also effective connectivity regarding both brain networks and brain regions by using a novel analysis framework that combines independent component analysis (ICA) and Granger causality analysis (GCA). We conducted a resting-state fMRI experiment in which twenty-one heavy smokers were scanned in two sessions of different conditions: smoking abstinence followed by smoking satiety. In our framework, group ICA was firstly adopted to obtain the spatial patterns of the default-mode network (DMN), executive-control network (ECN), and salience network (SN). Their associated time courses were analyzed using GCA, showing that the effective connectivity from SN to DMN was reduced and that from ECN/DMN to SN was enhanced after smoking replenishment. A paired t-test on ICA spatial patterns revealed functional connectivity variation in regions such as the insula, parahippocampus, precuneus, anterior cingulate cortex, supplementary motor area, and ventromedial/dorsolateral prefrontal cortex. These regions were later selected as the regions of interest (ROIs), and their effective connectivity was investigated subsequently using GCA. In smoking abstinence, the insula showed the increased effective connectivity with the other ROIs; while in smoking satiety, the parahippocampus had the enhanced inter-area effective connectivity. These results demonstrate our hypothesis that for deprived heavy smokers, smoking replenishment takes effect on both functional and effective connectivity. Moreover, our analysis framework could be applied in a range of neuroscience studies.
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