ArticlePloS one2013
Genetic variation in circadian rhythm genes CLOCK and ARNTL as risk factor for male infertility.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Circadian rhythm disruption in cardiovascular disease: a systematic review and meta-analysis of mechanistic evidence from animal models.BMC medicine · 2026Pooled it
- An update on the role and potential mechanisms of clock genes regulating spermatogenesis: A systematic review of human and animal experimental studies.Reviews in endocrine & metabolic disorders · 2023Pooled it
- Effects of Sleep Disorders and Circadian Rhythm Changes on Male Reproductive Health: A Systematic Review and Meta-analysis.Frontiers in physiology · 2022Pooled it
- The Circadian-Light-Hygiene Hypothesis: A Potential Modulator of Fertility and Birthrate Trends.Biology · 2026Review
- Reviewing the Implication of Aldehyde Dehydrogenases in Male Reproduction: Prospects for New Therapeutic Approaches.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Protection byPharmaceuticals (Basel, Switzerland) · 2026Article
- Regulation of testosterone synthesis by circadian clock genes and its research progress in male diseases.Asian journal of andrology · 2025Review
- The circadian clock orchestrates spermatogonial differentiation and fertilization by regulating retinoic acid signaling in vertebrates.National science review · 2025Article
- A time for sex: circadian regulation of mammalian sexual and reproductive function.Frontiers in neuroscience · 2024Review
- Diurnal rhythm of human semen quality: analysis of large-scale human sperm bank data and timing-controlled laboratory study.Human reproduction (Oxford, England) · 2022Article
- Analysis on the desert adaptability of indigenous sheep in the southern edge of Taklimakan Desert.Scientific reports · 2022Article
- Comparative transcriptome between male fertile and male sterile alfalfa (Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Every Night and Every Morn: Effect of Variation inFrontiers in psychiatry · 2021Article
- Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease.Frontiers in genetics · 2021Review
- Genipin improves reproductive health problems caused by circadian disruption in male mice.Reproductive biology and endocrinology : RB&E · 2020Article
- Family History as an Important Factor for Stratifying Participants in Genetic Studies of Major Depression.Balkan journal of medical genetics : BJMG · 2018Article
- Article
- Expression of the Circadian Clock GeneFrontiers in oncology · 2018Article
- Genetic variation in the CLOCK gene is associated with idiopathic recurrent spontaneous abortion.PloS one · 2018Article
- Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature.International journal of endocrinology · 2016Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe circadian system has a major role in maintaining homeostasis and proper body functions including reproductive capacity. The aim of this study was to examine whether there is an association between genetic variability in the primary clock genes CLOCK and ARNTL and male infertility in humans. METHODOLOGY/PRINCIPAL
findingsWe performed a case-control study, where we searched for an association between polymorphisms of CLOCK and ARNTL genes and male infertility in 961 Slovenian and Serbian Caucasian men. The study group consisted of 517 patients with idiopathic infertility and a control group of 444 fertile men. A statistically significant difference was found in genotype distribution between the two groups in the CLOCK gene: rs11932595 (p = 6·10(-5), q = 4·10(-4), OR equaled 1.9 with 95% CI 1.4-2.7), rs6811520 (p = 2·10(-3), q = 8·10(-3), OR = 1.7 with 95% CI 1.2-2.2) and rs6850524 (p = 0.01, q = 0.02, OR = 1.4 with 95% CI 1.1-1.9). Further analyses of haplotypes were consistent with genotyping results. CONCLUSIONS/SIGNIFICANCE: We provide evidence that genetic variability in the CLOCK gene might be associated with male infertility warranting further confirmation and mechanistic investigations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.