ArticlePloS one2013
Microstructural white matter changes in the corpus callosum of young people with Bipolar Disorder: a diffusion tensor imaging study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Role of magnetic resonance spectroscopy in cerebral glutathione quantification for youth mental health: A systematic review.Early intervention in psychiatry · 2020Pooled it
- Psychoradiologic abnormalities of white matter in patients with bipolar disorder: diffusion tensor imaging studies using tract-based spatial statisticsJournal of psychiatry & neuroscience : JPN · 2019Pooled it
- Meta-analysis of regional white matter volume in bipolar disorder with replication in an independent sample using coordinates, T-maps, and individual MRI data.Neuroscience and biobehavioral reviews · 2018Pooled it
- The underlying neurobiology of key functional domains in young people with mood and anxiety disorders: a systematic review.BMC psychiatry · 2016Pooled it
- Article
- Contribution of Myelin Damage to White Matter Changes in Osmotic Demyelination Syndrome.Diagnostics (Basel, Switzerland) · 2026Article
- Distinguished Frontal White Matter Abnormalities Between Psychotic and Nonpsychotic Bipolar Disorders in a Pilot Study.Brain sciences · 2025Article
- Shared and distinct white matter abnormalities in adolescent-onset schizophrenia and adolescent-onset psychotic bipolar disorder.Psychological medicine · 2023Article
- Disrupted white matter microstructure correlates with impulsivity in children and adolescents with bipolar disorder.Journal of psychiatric research · 2023Article
- Differences in network properties of the structural connectome in bipolar and unipolar depression.Psychiatry research. Neuroimaging · 2022Article
- Single episode brief psychotic disorder versus bipolar disorder: A diffusion tensor imaging and executive functions study.Schizophrenia research. Cognition · 2022Review
- White matter integrity in young medication-naïve bipolar II depressed adults.Scientific reports · 2021Article
- Psychiatric disorders in multiple sclerosis.Journal of neurology · 2021Review
- White matter correlates of cognitive flexibility in youth with bipolar disorder and typically developing children and adolescents.Psychiatry research. Neuroimaging · 2020Article
- Cyberbullying and Adolescent Neurobiology.Frontiers in psychology · 2020Review
- White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging.Scientific reports · 2018Article
- Preliminary mapping of the structural effects of age in pediatric bipolar disorder with multimodal MR imaging.Psychiatry research. Neuroimaging · 2018Article
- In vivo imaging of oxidative stress and fronto-limbic white matter integrity in young adults with mood disorders.European archives of psychiatry and clinical neuroscience · 2018Article
- Physical activity is associated with left corticospinal tract microstructure in bipolar depression.NeuroImage. Clinical · 2018Article
- Interhemispheric functional disconnection because of abnormal corpus callosum integrity in bipolar disorder type II.BJPsych open · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, most studies of white matter changes in Bipolar Disorder (BD) have been conducted in older subjects and with well-established disorders. Studies of young people who are closer to their illness onset may help to identify core neurobiological characteristics and separate these from consequences of repeated illness episodes or prolonged treatment. Diffusion tensor imaging (DTI) was used to examine white matter microstructural changes in 58 young patients with BD (mean age 23 years; range 16-30 years) and 40 controls. Whole brain voxelwise measures of fractional anisotropy (FA), parallel diffusivity (λ//) and radial diffusivity (λ⊥) were calculated for all subjects. White matter microstructure differences (decreased FA corrected p<.05) were found between the patients with BD and controls in the genu, body and splenium of the corpus callosum as well as the superior and anterior corona radiata. In addition, significantly increased radial diffusivity (p<.01) was found in the BD group. Neuroimaging studies of young patients with BD may help to clarify neurodevelopmental aspects of the illness and for identifying biomarkers of disease onset and progression. Our findings provide evidence of microstructural white matter changes early in the course of illness within the corpus callosum and the nature of these changes suggest they are associated with abnormalities in the myelination of axons.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.