ArticlePloS one2013
Regeneration of soft tissues is promoted by MMP1 treatment after digit amputation in mice.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Targeting lymphatic vessels enhances bone regeneration by augmenting osteoclast activity in mouse models of amputation.The Journal of clinical investigation · 2026Article
- Mouse digit AAV gene delivery into fibroblasts regulates regenerative outcome.Science advances · 2026Article
- Immunomodulatory Potential of a Composite Amniotic Membrane Hydrogel for Wound Healing: Effects on Macrophage Cytokine Secretion.Biomedicines · 2025Article
- Matrix Metalloproteinases and Their Inhibitors in the Pathogenesis of Epithelial Differentiation, Vascular Disease, Endometriosis, and Ocular Fibrotic Pterygium.International journal of molecular sciences · 2025Review
- Exploring the wound-healing potential and seasonal chemical variability of the Formosan Callery pearPharmaceutical biology · 2024Article
- Screening of the Skin-Regenerative Potential of Antimicrobial Peptides: Clavanin A, Clavanin-MO, and Mastoparan-MO.International journal of molecular sciences · 2024Article
- Article
- The Decellularized Cell-Derived Extracellular Matrix Enhances the Paracrine Function of Human Mesenchymal Stromal/Stem Cells.International journal of molecular sciences · 2024Article
- Deer antler renewal gives insights into mammalian epimorphic regeneration.Cell regeneration (London, England) · 2023Review
- The Effect of MMP-1 on Wound Healing and Scar Formation.Aesthetic plastic surgery · 2023Article
- Toeing the line between regeneration and fibrosis.Frontiers in cell and developmental biology · 2023Review
- The Potential of Nail Mini-Organ Stem Cells in Skin, Nail and Digit Tips Regeneration.International journal of molecular sciences · 2021Review
- Leucocyte-Rich Platelet-Rich Plasma Enhances Fibroblast and Extracellular Matrix Activity: Implications in Wound Healing.International journal of molecular sciences · 2020Article
- Transcriptomic analysis of bone and fibrous tissue morphogenesis during digit tip regeneration in the adult mouse.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Influence of Obesity on the Organization of the Extracellular Matrix and Satellite Cell Functions After Combined Muscle and Thorax Trauma in C57BL/6J Mice.Frontiers in physiology · 2020Article
- Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic.Journal of sports medicine (Hindawi Publishing Corporation) · 2020Review
- Histology and molecular pathology of iliotibial tract contracture in patients with gluteal muscle contracture.Bioscience reports · 2019Article
- Digit Tip Injuries: Current Treatment and Future Regenerative Paradigms.Stem cells international · 2019Review
- Digit Tip Regeneration: Merging Regeneration Biology with Regenerative Medicine.Stem cells translational medicine · 2018Article
- The periosteal requirement and temporal dynamics of BMP2-induced middle phalanx regeneration in the adult mouse.Regeneration (Oxford, England) · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ratio of matrix metalloproteinases (MMPs) to the tissue inhibitors of metalloproteinases (TIMPs) in wounded tissues strictly control the protease activity of MMPs, and therefore regulate the progress of wound closure, tissue regeneration and scar formation. Some amphibians (i.e. axolotl/newt) demonstrate complete regeneration of missing or wounded digits and even limbs; MMPs play a critical role during amphibian regeneration. Conversely, mammalian wound healing re-establishes tissue integrity, but at the expense of scar tissue formation. The differences between amphibian regeneration and mammalian wound healing can be attributed to the greater ratio of MMPs to TIMPs in amphibian tissue. Previous studies have demonstrated the ability of MMP1 to effectively promote skeletal muscle regeneration by favoring extracellular matrix (ECM) remodeling to enhance cell proliferation and migration. In this study, MMP1 was administered to the digits amputated at the mid-second phalanx of adult mice to observe its effect on digit regeneration. Results indicated that the regeneration of soft tissue and the rate of wound closure were significantly improved by MMP1 administration, but the elongation of the skeletal tissue was insignificantly affected. During digit regeneration, more mutipotent progenitor cells, capillary vasculature and neuromuscular-related tissues were observed in MMP1 treated tissues; moreover, there was less fibrotic tissue formed in treated digits. In summary, MMP1 was found to be effective in promoting wound healing in amputated digits of adult mice.
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