ArticlePloS one2013
Spontaneous detachment of the leading head contributes to myosin VI backward steps.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Processivity and Velocity for Motors Stepping on Periodic Tracks.Biophysical journal · 2020Article
- A programmable DNA origami nanospring that reveals force-induced adjacent binding of myosin VI heads.Nature communications · 2016Article
- Lever arm extension of myosin VI is unnecessary for the adjacent binding state.Biophysics (Nagoya-shi, Japan) · 2015Review
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Authors and funding
3 authors.
Funding
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Abstract
Myosin VI is an ATP driven molecular motor that normally takes forward and processive steps on actin filaments, but also on occasion stochastic backward steps. While a number of models have attempted to explain the backwards steps, none offer an acceptable mechanism for their existence. We therefore performed single molecule imaging of myosin VI and calculated the stepping rates of forward and backward steps at the single molecule level. The forward stepping rate was proportional to the ATP concentration, whereas the backward stepping rate was independent. Using these data, we proposed that spontaneous detachment of the leading head is uncoupled from ATP binding and is responsible for the backward steps of myosin VI.
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