ArticlePloS one2013
Increasing maternal age is associated with taller stature and reduced abdominal fat in their children.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Exercise in pregnancy: 1-year and 7-year follow-ups of mothers and offspring after a randomized controlled trial.Scientific reports · 2018Trial
- Adiposity trajectory as a predictor of chronic and multisite pain in the transition from childhood to adolescence: A prospective study of a large birth cohort.International journal of obesity (2005) · 2026Article
- Association between parental age at childbirth and timing of puberty in children: an 8-year cohort study.Biology of sex differences · 2026Article
- The Association Between Maternal Age at Childbirth and Child Nutritional Outcomes: A Cross-sectional Study From Serbian Roma Communities.Global pediatric health · 2024Article
- Relationship between Birth Order and Postnatal Growth until 4 Years of Age: The Japan Environment and Children's Study.Children (Basel, Switzerland) · 2023Article
- Parental determinants associated with early growth after the first year of life by race and ethnicity.Frontiers in pediatrics · 2023Article
- Secular trends and sociodemographic determinants of thinness, overweight and obesity among Chinese children and adolescents aged 7-18 years from 2010 to 2018.Frontiers in public health · 2023Article
- Fetal programming of human energy homeostasis brain networks: Issues and considerations.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- Article
- Persistent epigenetic changes in adult daughters of older mothers.Epigenetics · 2019Article
- Mother's age at delivery and daughters' risk of preeclampsia.Paediatric and perinatal epidemiology · 2019Article
- Associations of maternal, perinatal and postnatal factors with the eruption timing of the first primary tooth.Scientific reports · 2019Article
- Parental weight status and early adolescence body weight in association with socioeconomic factors.Journal of education and health promotion · 2019Article
- Mode of infant feeding, eating behaviour and anthropometry in infants at 6-months of age born to obese women - a secondary analysis of the UPBEAT trial.BMC pregnancy and childbirth · 2018Article
- Microbes in Infant Gut Development: Placing Abundance Within Environmental, Clinical and Growth Parameters.Scientific reports · 2017Article
- Associations of parental age with health and social factors in adult offspring. Methodological pitfalls and possibilities.Scientific reports · 2017Article
- Article
- Influence of metabolic-linked early life factors on the eruption timing of the first primary tooth.Clinical oral investigations · 2016Article
- Advanced maternal age causes adverse programming of mouse blastocysts leading to altered growth and impaired cardiometabolic health in post-natal life.Human reproduction (Oxford, England) · 2016Article
- Bisphenol a exposure disrupts metabolic health across multiple generations in the mouse.Endocrinology · 2015Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMaternal age at childbirth continues to increase worldwide. We aimed to assess whether increasing maternal age is associated with changes in childhood height, body composition, and metabolism.
methods277 healthy pre-pubertal children, born 37-41 weeks gestation were studied. Assessments included: height and weight corrected for parental measurements, DEXA-derived body composition, fasting lipids, glucose, insulin, and hormonal profiles. Subjects were separated according to maternal age at childbirth: <30, 30-35, and >35 years.
resultsOur cohort consisted of 126 girls and 151 boys, aged 7.4 ± 2.2 years (range 3-10); maternal age at childbirth was 33.3 ± 4.7 years (range 19-44). Children of mothers aged >35 and 30-35 years at childbirth were taller than children of mothers aged <30 years by 0.26 (p = 0.002) and 0.23 (p = 0.042) SDS, respectively. There was a reduction in childhood BMISDS with increasing maternal age at childbirth, and children of mothers aged >35 years at childbirth were 0.61 SDS slimmer than those of mothers <30 years (p = 0.049). Children of mothers aged 30-35 (p = 0.022) and >35 (p = 0.036) years at childbirth had abdominal adiposity reduced by 10% and 13%, respectively, compared to those in the <30 group. Children of mothers aged 30-35 years at childbirth displayed a 19% increase in IGF-I concentrations compared to offspring in <30 group (p = 0.042). Conversely, IGF-II concentrations were lower among the children born to mothers aged 30-35 (6.5%; p = 0.004) and >35 (8.1%; p = 0.005) compared to those of mothers aged <30 years. Girls of mothers aged 30-35 years at childbirth also displayed improved HOMA-IR insulin sensitivity (p = 0.010) compared to girls born to mothers aged <30 years.
conclusionsIncreasing maternal age at childbirth is associated with a more favourable phenotype (taller stature and reduced abdominal fat) in their children, as well as improved insulin sensitivity in girls.
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