ArticlePloS one2013
Transcriptome analysis on Chinese shrimp Fenneropenaeus chinensis during WSSV acute infection.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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52 citing papers in PubMed, 173 citations in OpenAlex.
- The Regulatory Effect and Molecular Mechanism of the Anti-Lipopolysaccharide Factor-like Gene on the Resistance of Shrimp (Animals : an open access journal from MDPI · 2025Article
- Host Defense Proteins and Peptides with Lipopolysaccharide-Binding Activity from Marine Invertebrates and Their Therapeutic Potential in Gram-Negative Sepsis.Marine drugs · 2023Review
- MicroRNA Regulation in Infectious Diseases and Its Potential as a Biosensor in Future Aquaculture Industry: A Review.Molecules (Basel, Switzerland) · 2023Review
- Marine Arthropods as a Source of Antimicrobial Peptides.Marine drugs · 2022Review
- Molecular and Functional Characterization of an Anti-lipopolysaccharide Factor Mm-ALF from Speckled Shrimp Metapenaeus monoceros.Probiotics and antimicrobial proteins · 2021Article
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- A Lymphoid Organ Specific Anti-Lipopolysaccharide Factor fromMarine drugs · 2021Article
- The Molecular Mechanism of Hemocyte Immune Response inFrontiers in microbiology · 2021Article
- De Novo Transcriptome Assembly and Gene Expression Profiling of the CopepodMarine drugs · 2020Article
- Shedding the Light onGenes · 2020Article
- Molecular and Functional Diversity of Crustin-Like Genes in the ShrimpMarine drugs · 2020Article
- Article
- Transcriptome analysis reveals the activation of neuroendocrine-immune system in shrimp hemocytes at the early stage of WSSV infection.BMC genomics · 2019Article
- Article
- Characterization of a Lymphoid Organ Specific Anti-lipopolysaccharide Factor From Shrimp Reveals Structure-Activity Relationship of the LPS-Binding Domain.Frontiers in immunology · 2019Article
- Genetic Variation in Disease Resistance Against White Spot Syndrome Virus (WSSV) inFrontiers in genetics · 2019Article
- Identification of Functional Gene Modules Associated With STAT-Mediated Antiviral Responses to White Spot Syndrome Virus in Shrimp.Frontiers in physiology · 2019Article
- Single-molecule long-read sequencing facilitates shrimp transcriptome research.Scientific reports · 2018Article
- De novo assembly, characterization, functional annotation and expression patterns of the black tiger shrimp (Penaeus monodon) transcriptome.Scientific reports · 2018Article
- The State of "Frontiers in genetics · 2018Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have discovered a lot of immune-related genes responding to white spot syndrome virus (WSSV) infection in crustacean. However, little information is available in relation to underlying mechanisms of host responses during the WSSV acute infection stage in naturally infected shrimp. In this study, we employed next-generation sequencing and bioinformatic techniques to observe the transcriptome differences of the shrimp between latent infection stage and acute infection stage. A total of 64,188,426 Illumina reads, including 31,685,758 reads from the latent infection group and 32,502,668 reads from the acute infection group, were generated and assembled into 46,676 unigenes (mean length: 676 bp; range: 200-15,094 bp). Approximately 24,000 peptides were predicted and classified based on homology searches, gene ontology, clusters of orthologous groups of proteins, and biological pathway mapping. Among which, 805 differentially expressed genes were identified and categorized into 11 groups based on their possible function. Genes in the Toll and IMD pathways, the Ras-activated endocytosis process, the RNA interference pathway, anti-lipopolysaccharide factors and many other genes, were found to be activated in shrimp from latent infection stage to acute infection stage. The anti-bacterially proPO-activating cascade was firstly uncovered to be probably participated in antiviral process. These genes contain not only members playing function in host defense against WSSV, but also genes utilized by WSSV for its rapid proliferation. In addition, the transcriptome data provides detail information for identifying novel genes in absence of the genome database of shrimp.
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