Trial reportJournal of magnetic resonance imaging : JMRI2013
BOLD fMRI in infants under sedation: Comparing the impact of pentobarbital and propofol on auditory and language activation.
Trial report in Journal of magnetic resonance imaging : JMRI, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Propofol sedation in children: sleep trumps amnesia.Sleep medicineTrial
- Bridging Genes and Behavior in Autism Spectrum Disorder: Contributions of OXTR Gene Variants and Methylation to Brain Connectivity Patterns.Psychiatry investigation · 2026Article
- Imaging and Anesthesia Protocol Optimization in Sedated Clinical Resting-State fMRI.AJNR. American journal of neuroradiology · 2025Article
- Intrinsic network abnormalities in children with autism spectrum disorder: an independent component analysis.Brain imaging and behavior · 2024Article
- Navigated Transcranial Magnetic Stimulation Motor Mapping and Diffusion Tensor Imaging Tractography for Diencephalic Tumor in Pediatric Patients.Brain sciences · 2023Article
- Alterations in Social Brain Network Topology at Rest in Children With Autism Spectrum Disorder.Psychiatry investigation · 2022Article
- Brain perfusion magnetic resonance imaging using pseudocontinuous arterial spin labeling in 314 dogs and cats.Journal of veterinary internal medicine · 2021Article
- Arterial spin labeling brain MRI study to evaluate the impact of deafness on cerebral perfusion in 79 children before cochlear implantation.NeuroImage. Clinical · 2021Article
- Structural neuroimaging of the altered brain stemming from pediatric and adolescent hearing loss-Scientific and clinical challenges.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Increased Functional Connectivity Within and Between Cognitive-Control Networks from Early Infancy to Nine Years During Story Listening.Brain connectivity · 2019Article
- Developmental changes in functional brain networks from birth through adolescence.Human brain mapping · 2019Article
- Disrupted neural variability during propofol-induced sedation and unconsciousness.Human brain mapping · 2018Article
- Altered functional network connectivity in preterm infants: antecedents of cognitive and motor impairments?Brain structure & function · 2018Article
- Methodological challenges in the comparison of infant fMRI across age groups.Developmental cognitive neuroscience · 2018Review
- Memory formation during anaesthesia: plausibility of a neurophysiological basis.British journal of anaesthesia · 2015Review
- Article
- Combined analysis of sMRI and fMRI imaging data provides accurate disease markers for hearing impairment.NeuroImage. Clinical · 2013Article
- Is Orally Administered Pentobarbital a Safe and Effective Alternative to Chloral Hydrate for Pediatric Procedural Sedation?The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo elucidate differences in the disruption of language network function, as measured by blood oxygenation level-dependent (BOLD) contrast functional MRI (fMRI), attributable to two common sedative agents administered to infants under clinical imaging protocols. MATERIALS AND
methodsThe sedatives pentobarbital (Nembutal) and Propofol, administered clinically to infants at 1 year of age, were compared with respect to BOLD activation profiles in response to passive story-listening stimulation. An intermittent event-related imaging protocol was used with which the temporal evolution of language processing resulting from this stimulation was explored.
resultsPropofol and Nembutal were found to have distinct and complementary responses to story-listening. Propofol exhibited more activation in higher processing networks with increasing response toward the end of narrative stimulus. Nembutal, in contrast, had much more robust activation of primary and secondary sensory cortices but a decreasing response over time in fronto-parietal default-mode regions. This may suggest a breakdown of top-down feedback for Propofol versus the lack of bottom-up feed-forward processing for Nembutal.
conclusionTwo popular sedative agents for use in children for clinical fMRI were found to induce distinct alteration of activation patterns from a language stimulus. This has ramifications for clinical fMRI of sedated infants and encourages further study to build a framework for more confident interpretation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.