ArticleProteins2013
Crystal structure of SsfS6, the putative C-glycosyltransferase involved in SF2575 biosynthesis.
Article in Proteins, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Biosynthesis and Microbial Production of Carminic Acid: From Pathway Elucidation to Synthetic Biology.Microorganisms · 2026Review
- Structural mechanism of a dual-functional enzyme DgpA/B/C as both aActa pharmaceutica Sinica. B · 2023Article
- Exploring the catalytic function and active sites of a novelSynthetic and systems biotechnology · 2022Article
- OleD Loki as a Catalyst for Hydroxamate Glycosylation.Chembiochem : a European journal of chemical biology · 2020Article
- Genome Sequence and Composition of a Tolyporphin-Producing Cyanobacterium-Microbial Community.Applied and environmental microbiology · 2017Article
- OleD Loki as a Catalyst for Tertiary Amine and Hydroxamate Glycosylation.Chembiochem : a European journal of chemical biology · 2017Article
- Enzymatic synthesis of glycosides: from naturalBeilstein journal of organic chemistry · 2017Review
- Loop dynamics of thymidine diphosphate-rhamnose 3'-O-methyltransferase (CalS11), an enzyme in calicheamicin biosynthesis.Structural dynamics (Melville, N.Y.) · 2016Article
- A comprehensive review of glycosylated bacterial natural products.Chemical Society reviews · 2015Review
- Structural characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2.Angewandte Chemie (International ed. in English) · 2015Article
- Advances in understanding glycosyltransferases from a structural perspective.Current opinion in structural biology · 2014Review
- Structural studies of the spinosyn forosaminyltransferase, SpnP.Biochemistry · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The molecule known as SF2575 from Streptomyces sp. is a tetracycline polyketide natural product that displays antitumor activity against murine leukemia P388 in vivo. In the SF2575 biosynthetic pathway, SsfS6 has been implicated as the crucial C-glycosyltransferase (C-GT) that forms the C-C glycosidic bond between the sugar and the SF2575 tetracycline-like scaffold. Here, we report the crystal structure of SsfS6 in the free form and in complex with TDP, both at 2.4 Å resolution. The structures reveal SsfS6 to adopt a GT-B fold wherein the TDP and docked putative aglycon are consistent with the overall C-glycosylation reaction. As one of only a few existing structures for C-glycosyltransferases, the structures described herein may serve as a guide to better understand and engineer C-glycosylation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.