Evidence map›Paper›PMID 23526571›Full record

ArticleACS medicinal chemistry letters2013

Discovery of a Series of Thiazole Derivatives as Novel Inhibitors of Metastatic Cancer Cell Migration and Invasion.

Shilong Zheng, Qiu Zhong, Quan Jiang, Madhusoodanan Mottamal, Qiang Zhang, Naijue Zhu, Matthew E Burow, Rebecca A Worthylake, Guangdi Wang

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Shilong ZhengDepartment of Chemistry, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125.
Qiu Zhong
Quan Jiang
Madhusoodanan Mottamal
Qiang Zhang
Naijue Zhu
Matthew E Burow
Rebecca A Worthylake
Guangdi Wang
Louisiana State University Health Sciences Center New Orleans · USTulane University · USXavier University of Louisiana · US

Funding

Xavier's RCMI Cancer Research ProgramG12MD007595 · NIMHD · XAVIER UNIVERSITY OF LOUISIANA · PI D'AMOUR, GENE, WANG, GUANGDI · 2012 to 2018
$15.7M
XAVIER'S RCMI CANCER RESEARCH PROGRAMG12RR026260 · NCRR · XAVIER UNIVERSITY OF LOUISIANA · PI WIESE, THOMAS E · 2009 to 2011
$7.0M
MEK5-Erk5 in breast cancer resistanceR01CA125806 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI BUROW, MATTHEW E. · 2010 to 2014
$1.5M
NCI NIH HHS R01 CA125806NCRR NIH HHS G12 RR026260NIMHD NIH HHS G12 MD007595
6 · The paper itself

Abstract

Effective inhibitors of cancer cell migration and invasion can potentially lead to clinical applications as therapy to block tumor metastasis, the primary cause of death in cancer patients. To this end we have designed and synthesized a series of thiazole derivatives that showed potent efficacy against cell migration and invasion in metastatic cancer cells. The most effective compound,

Indexed as

anti-invasionanti-migrationf-actinfascinsynthesisThiazole derivatives

Identifiers

PMID23526571
PMCPMC3601768
OpenAlexW2037394566

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.