ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2013
Etiology, clinical profile, and inhospital mortality of acute-on-chronic liver failure: a prospective study.
Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Article
- Effect of Artificial Liver Support Systems on Gut Microbiota in Patients with HBV-Related Acute-on-Chronic Liver Failure.Pathogens (Basel, Switzerland) · 2023Article
- Acute-on-chronic liver failure: Terminology, mechanisms and management.Clinical and molecular hepatology · 2023Review
- Tenofovir alafenamide versus entecavir for treating hepatitis B virus-related acute-on-chronic liver failure: real-world study.Frontiers in microbiology · 2023Article
- Dengue hemorrhagic fever and the liver.World journal of hepatology · 2021Review
- Baseline serum cystatin C as a marker of acute kidney injury in patients with acute-on-chronic liver failure.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Observational
- Predictors of early mortality among patients with acute-on-chronic liver failure.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Neurological manifestations of hepatitis E virus infection: An overview.World journal of gastroenterology · 2021Review
- Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update.Hepatology international · 2019Article
- Acute on Chronic Liver Failure-In-Hospital Predictors of Mortality in ICU.Journal of clinical and experimental hepatology · 2018Article
- Role of Hepatitis E Virus Infection in Acute-on-Chronic Liver Failure.BioMed research international · 2018Review
- Effect of replenishment of vitamin D on survival in patients with decompensated liver cirrhosis: A prospective study.World journal of gastrointestinal pathophysiology · 2017Article
- Characteristics and outcomes of chronic liver disease patients with acute deteriorated liver function by severity of underlying liver disease.World journal of gastroenterology · 2016Article
- Overview on acute-on-chronic liver failure.Frontiers of medicine · 2016Review
- Acute-on-Chronic Liver Failure (ACLF) in Coastal Eastern India: "A Single-Center Experience".Journal of clinical and experimental hepatology · 2016Article
- Role of non-hepatotropic viruses in acute sporadic viral hepatitis and acute-on-chronic liver failure in adults.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2015Article
- Pattern and profile of chronic liver disease in acute on chronic liver failure.Hepatology international · 2015Review
- Dengue and its effects on liver.World journal of clinical cases · 2015Review
- Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014.Hepatology international · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe causes of acute injury in acute-on-chronic liver failure (ACLF) are variable. There may be simultaneous presence of more than one acute insult. We describe the clinical profile of ACLF and the effect of dual acute insult on the natural history.
methodsPatients with jaundice diagnosed to have ACLF were prospectively enrolled. Patients were evaluated for the clinical presentation, etiology of acute decompensation and underlying chronic liver disease, and inhospital mortality. We compared the clinical profile of patients who had dual acute insult with those of single/unknown insult.
resultsFifty-two patients with ACLF (mean age 38.6 ± 16.7 years; M/F 41:11) were included. Hepatitis virus infection (46.1 %) and bacterial infection (36.5 %) were the most common acute insults. Hepatitis virus infections were the sole acute insult in 34.6 % and associated with another injury in 11.5 %. Bacterial infections were identified as acute insult in 19 patients (sole acute insult in 13). Drugs, autoimmune disease, surgery, malaria, and dengue were other acute injuries identified. The cause of acute decompensation was unknown in 11.5 %. Mortality (66.6 % vs. 51.1 %) was higher in patients with dual insult (n=9) as compared with single/unknown insult (n=43).
conclusionsHepatitis virus and bacterial infection/sepsis were the common acute insults in ACLF. Dual acute insult is not uncommon, poses diagnostic dilemma, and may increase mortality in these patients. Plasmodium falciparum infection and dengue fever may be associated with ACLF.
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