ReviewCurrent cardiology reports2013
Mechanisms of calcification in aortic valve disease: role of mechanokinetics and mechanodynamics.
Review in Current cardiology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Capturing Multiscale Dynamics of Aortic Valve Calcification with a Coupled Fluid-Structure and Systems Biology Model.ACS omega · 2026Article
- PMCell biochemistry and biophysics · 2025Article
- Secreted Cytokines From Inflammatory Macrophages Modulate Sex Differences in Valvular Interstitial Cells on Hydrogel Biomaterials.Journal of biomedical materials research. Part A · 2025Article
- Focusing on the Native Matrix Proteins in Calcific Aortic Valve Stenosis.JACC. Basic to translational science · 2023Review
- Predicting key gene related to immune infiltration and myofibroblast-like valve interstitial cells in patients with calcified aortic valve disease based on bioinformatics analysis.Journal of thoracic disease · 2023Article
- Osteopontin activity modulates sex-specific calcification in engineered valve tissue mimics.Bioengineering & translational medicine · 2023Article
- Fibroblast growth factor 2 inhibits myofibroblastic activation of valvular interstitial cells.PloS one · 2022Article
- Comparison of Serotonin-Regulated Calcific Processes in Aortic and Mitral Valvular Interstitial Cells.ACS omega · 2021Article
- Spatial N-glycomics of the human aortic valve in development and pediatric endstage congenital aortic valve stenosis.Journal of molecular and cellular cardiology · 2021Article
- Long-Term Stability and Biocompatibility of Pericardial Bioprosthetic Heart Valves.Frontiers in cardiovascular medicine · 2021Review
- Secreted Factors From Proinflammatory Macrophages Promote an Osteoblast-Like Phenotype in Valvular Interstitial Cells.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
- Bioorthogonal click chemistries enable simultaneous spatial patterning of multiple proteins to probe synergistic protein effects on fibroblast function.Biomaterials · 2020Article
- Article
- Notch1 suppression by microRNA-34a: a new mechanism of calcific aortic valve disease.Cardiovascular research · 2020Article
- Echocardiographic manifestations and chemical composition of stenotic bicuspid aortic valves.Journal of materials science. Materials in medicine · 2018Article
- Ideal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly Patients.Journal of the American Heart Association · 2018Observational
- Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges.Frontiers in cardiovascular medicine · 2018Review
- Proteomic Alterations Associated with Biomechanical Dysfunction are Early Processes in the Emilin1 Deficient Mouse Model of Aortic Valve Disease.Annals of biomedical engineering · 2017Article
- Sex-related differences in matrix remodeling and early osteogenic markers in aortic valvular interstitial cells.Heart and vessels · 2017Article
- Cardiovascular Organ-on-a-Chip Platforms for Drug Discovery and Development.Applied in vitro toxicology · 2016Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The aortic valve is highly responsive to cyclical and continuous mechanical forces, at the macroscopic and cellular levels. In this report, we delineate mechanokinetics (effects of mechanical inputs on the cells) and mechanodynamics (effects of cells and pathologic processes on the mechanics) of the aortic valve, with a particular focus on how mechanical inputs synergize with the inflammatory cytokine and other biomolecular signaling to contribute to the process of aortic valve calcification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.