Evidence map›Paper›PMID 23526214›Full record

ArticleAmerican journal of respiratory cell and molecular biology2013

Role of migratory inhibition factor in age-related susceptibility to radiation lung injury via NF-E2-related factor-2 and antioxidant regulation.

Biji Mathew, Jeffrey R Jacobson, Jessica H Siegler, Jaideep Moitra, Michael Blasco, Lishi Xie, Crystal Unzueta, Tong Zhou, Carrie Evenoski, Mohammed Al-Sakka and 13 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Plasticity towards Rigidity: A Macrophage Conundrum in Pulmonary Fibrosis.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Review
  10. Involvement of eNAMPT/TLR4 signaling in murine radiation pneumonitis: protection by eNAMPT neutralization.Translational research : the journal of laboratory and clinical medicine · 2022
    Article
  11. Article
  12. My Journey in Academia as a Lipid Biochemist.Cell biochemistry and biophysics · 2021
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Cytokines and radiation-induced pulmonary injuries.Journal of radiation research · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 2 countries.

Biji MathewInstitute for Personalized Respiratory Medicine, University of Illinois at Chicago, Chicago, IL 60612-7227, USA.
Jeffrey R Jacobson
Jessica H Siegler
Jaideep Moitra
Michael Blasco
Lishi Xie
Crystal Unzueta
Tong Zhou
Carrie Evenoski
Mohammed Al-Sakka
Rajesh Sharma
Ben Huey
Aydogan Bulent
Brett Smith
Sundararajan Jayaraman
Narsa M Reddy
Shekhar P Reddy
Günter Fingerle-Rowson
Richard Bucala
Steven M Dudek
Viswanathan Natarajan
Ralph R Weichselbaum
Joe G N Garcia
University of Illinois Chicago · USUniversity of Chicago · USUniversity Hospital Cologne · DEYale University · US

Funding

Tissue Culture Biomechanical CoreP01HL058064 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAL, RATNESHWAR · 1998 to 2012
$27.8M
Therapeutic Potential of FTY720 Analogues in Lung InjuryP01HL098050 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI NATARAJAN, VISWANATHAN · 2011 to 2015
$10.9M
MIF AND THE HOST RESPONSE TO INFECTIONR01AI042310 · NIAID · YALE UNIVERSITY · PI BUCALA, RICHARD J · 1998 to 2013
$4.3M
MIF and Host Response to InfectionR56AI042310 · NIAID · YALE UNIVERSITY · PI BUCALA, RICHARD J · 2014 to 2014
$426k
NHLBI NIH HHS HL 58094NHLBI NIH HHS P01 HL058064NHLBI NIH HHS P01 HL098050NIAID NIH HHS AI 42310NIAID NIH HHS R01 AI042310NIAID NIH HHS R56 AI042310
6 · The paper itself

Abstract

Microvascular injury and increased vascular leakage are prominent features of radiation-induced lung injury (RILI), and often follow cancer-associated thoracic irradiation. Our previous studies demonstrated that polymorphisms in the gene (MIF) encoding macrophage migratory inhibition factor (MIF), a multifunctional pleiotropic cytokine, confer susceptibility to acute inflammatory lung injury and increased vascular permeability, particularly in senescent mice. In this study, we exposed wild-type and genetically engineered mif(-/-) mice to 20 Gy single-fraction thoracic radiation to investigate the age-related role of MIF in murine RILI (mice were aged 8 wk, 8 mo, or 16 mo). Relative to 8-week-old mice, decreased MIF was observed in bronchoalveolar lavage fluid and lung tissue of 8- to 16-month-old wild-type mice. In addition, radiated 8- to 16-month-old mif(-/-) mice exhibited significantly decreased bronchoalveolar lavage fluid total antioxidant concentrations with progressive age-related decreases in the nuclear expression of NF-E2-related factor-2 (Nrf2), a transcription factor involved in antioxidant gene up-regulation in response to reactive oxygen species. This was accompanied by decreases in both protein concentrations (NQO1, GCLC, and heme oxygenase-1) and mRNA concentrations (Gpx1, Prdx1, and Txn1) of Nrf2-influenced antioxidant gene targets. In addition, MIF-silenced (short, interfering RNA) human lung endothelial cells failed to express Nrf2 after oxidative (H2O2) challenge, an effect reversed by recombinant MIF administration. However, treatment with an antioxidant (glutathione reduced ester), but not an Nrf2 substrate (N-acetyl cysteine), protected aged mif(-/-) mice from RILI. These findings implicate an important role for MIF in radiation-induced changes in lung-cell antioxidant concentrations via Nrf2, and suggest that MIF may contribute to age-related susceptibility to thoracic radiation.

Indexed as

Acute Lung InjuryAgingAnimalsBronchoalveolar Lavage FluidCells, CulturedGamma RaysHeme Oxygenase-1HumansHydrogen PeroxideIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMembrane ProteinsMiceMice, KnockoutNAD(P)H Dehydrogenase (Quinone)NF-E2-Related Factor 2Heme Oxygenase-1HMOX1 protein, humanHmox1 protein, mouseHydrogen PeroxideIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMembrane ProteinsMIF protein, humanMif protein, mouseNAD(P)H Dehydrogenase (Quinone)NFE2L2 protein, humanNfe2l2 protein, mouseNF-E2-Related Factor 2NQO1 protein, humanNqo1 protein, mouseOxidants

Identifiers

PMID23526214
PMCPMC3824032
OpenAlexW2123006075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.