Evidence map›Paper›PMID 23525955›Full record

ArticleOncoimmunology2013

Depletion of T lymphocytes is correlated with response to temozolomide in melanoma patients.

Trine Zeeberg Iversen, Marie Klinge Brimnes, Kirsten Nikolajsen, Rikke Sick Andersen, Sine Reker Hadrup, Mads Hald Andersen, Lars Bastholt, Inge Marie Svane

Abstract read
In one paragraph

Article in Oncoimmunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. [Abscopal effect in the treatment of malignant melanoma].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2015
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Trine Zeeberg IversenDepartment of Haematology and Oncology; Center for Cancer Immune Therapy (CCIT); Copenhagen University Hospital at Herlev; Herlev, Denmark.
Marie Klinge Brimnes
Kirsten Nikolajsen
Rikke Sick Andersen
Sine Reker Hadrup
Mads Hald Andersen
Lars Bastholt
Inge Marie Svane

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapeutic strategies to deplete lymphocytes, especially regulatory T cells, in cancer patients have been proposed to increase the benefits of (immuno)chemotherapy. In this study, we explored the influence of temozolomide (TMZ) on different T-cell populations and addressed if the depletion of CD4

Indexed as

lymphocyteslymphopeniametastatic melanomaregulatory T cellstemozolomide

Identifiers

PMID23525955
PMCPMC3601183

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.