ArticleImmunogenetics2013
Cost-effective procedures for genotyping of human FCN2 gene single nucleotide polymorphisms.
Article in Immunogenetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Polymorphisms in FCN genes and their influence on systemic lupus erythematosus susceptibility: a report from Western India.ImmunoHorizons · 2025Article
- Association of low ficolin-2 concentration in cord serum with respiratory distress syndrome in preterm newborns.Frontiers in immunology · 2023Article
- Association of theInternational journal of molecular sciences · 2022Article
- Polymorphisms of theFrontiers in immunology · 2021Article
- Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults.Scientific reports · 2020Article
- Associations of Ficolins With Hematological Malignancies in Patients Receiving High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantations.Frontiers in immunology · 2019Article
- Lectin pathway factors in patients suffering from juvenile idiopathic arthritis.Immunology and cell biology · 2017Article
- Frequency and distribution of FCN2 and FCN3 functional variants among MBL2 genotypes.Immunogenetics · 2016Article
- Ficolin-2 and ficolin-3 in women with malignant and benign ovarian tumours.Cancer immunology, immunotherapy : CII · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
L-ficolin (ficolin-2) is a complement-activating pattern-recognition lectin taking part in the innate immune response. Both its serum concentration and sugar binding capacity are influenced by single nucleotide polymorphisms (SNP) of the corresponding FCN2 gene. Cost-effective and simple procedures, based on polymerase chain reaction (PCR) or PCR-restriction fragment length polymorphism for an investigation of four FCN2 SNPs are proposed: -64 A > C (rs7865453), -4 A > G (rs17514136; both located in the promoter region), +6359 C > T (rs17549193), +6424 G > T (rs7851696; both in exon 8). Variant alleles of -64 and +6424 (in strong linkage disequlibrium) are known to be associated with low L-ficolin level or activity. In contrast, variant alleles at positions -4 and +6359 (also in strong linkage disequlibrium) correspond to higher values. Since several L-ficolin clinical associations have been reported, FCN2 genotyping seems to be a valuable tool for disease association studies.
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