ArticleCellular and molecular neurobiology2013
Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus.
Article in Cellular and molecular neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Hippocampal Nogo66-NgR1 signaling activation restricts postsynaptic assembly in aged mice with postoperative neurocognitive disorders.Aging cell · 2025Article
- LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB.Molecular medicine (Cambridge, Mass.) · 2022Article
- Article
- NgR1 pathway expression in cerebral ischemic Sprague-Dawley rats with cognitive impairment.Iranian journal of basic medical sciences · 2021Article
- LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation.Scientific reports · 2021Article
- Article
- LINGO-1 antibody ameliorates myelin impairment and spatial memory deficits in the early stage of 5XFAD mice.CNS neuroscience & therapeutics · 2018Article
- A Nogo-Like Signaling Perspective from Birth to Adulthood and in Old Age: Brain Expression Patterns of Ligands, Receptors and Modulators.Frontiers in molecular neuroscience · 2018Article
- Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery in aged mice.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Age-dependent decline of nogo-a protein in the mouse cerebrum.Cellular and molecular neurobiology · 2014Article
- Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Increased dynamin-1 and -2 protein expression in the aged gerbil hippocampus.Cellular and molecular neurobiology · 2014Article
- The role of reticulons in neurodegenerative diseases.Neuromolecular medicine · 2014Review
- Insulin-like growth factor-1 in CNS and cerebrovascular aging.Frontiers in aging neuroscience · 2013Article
- Human Umbilical Cord Mesenchymal Stem Cells Improve the Status of Hypoxic/Ischemic Cerebral Palsy Rats by Downregulating NogoA/NgR/Rho Pathway.Cell transplantationArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
The myelin-associated inhibitor/Nogo-66 receptor 1 (NgR1) pathway directly functions in negative modulation of structural and electrophysiological synaptic plasticity. A previous study has established an important role of NgR1 pathway signaling in cognitive function, and we have demonstrated that multiple components of this pathway, including ligands, NgR1 co-receptors, and RhoA, are upregulated at the protein level specifically in cognitively impaired, but not age-matched cognitively intact aged rats. Recent studies have identified two novel endogenous NgR1 antagonists, LOTUS and LGI1, and an alternative co-receptor, ADAM22, which act to suppress NgR1 pathway signaling. To determine whether these endogenous NgR1-inhibiting proteins may play a compensatory role in age-related cognitive impairment by counteracting overexpression of NgR1 agonists and co-receptors, we quantified the expression of LOTUS, LGI1, and ADAM22 in hippocampal CA1, CA3 and DG subregions dissected from mature adult and aged rats cognitively phenotyped for spatial learning and memory by Morris water maze testing. We have found that endogenous inhibitors of NgR1 pathway action decrease significantly with aging and cognitive decline and that lower expression levels correlate with declining cognitive ability, particularly in CA1 and CA3. These data suggest that decreased expression of NgR1-antagonizing proteins may exert a combinatorial effect with increased NgR1 signaling pathway components to result in abnormally strong suppression of synaptic plasticity in age-related cognitive impairment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.