Evidence map›Paper›PMID 23525677›Full record

ArticleVirchows Archiv : an international journal of pathology2013

Tubulocystic carcinoma of the kidney: a histologic, immunohistochemical, and ultrastructural study.

Borislav A Alexiev, Cinthia B Drachenberg

Abstract read
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021
    Guideline
  2. Article
  3. Article
  4. Article
  5. Article
  6. Tubulocystic carcinoma of the kidney.Proceedings (Baylor University. Medical Center) · 2015
    Article
  7. Review
  8. Diagnostic approach to eosinophilic renal neoplasms.Archives of pathology & laboratory medicine · 2014
    Review
  9. Review
  10. Uretheral invagination of multilocular cystic nephroma; a case report of a new pathologic variant.International journal of clinical and experimental pathology · 2014
    Article
  11. Tubulocystic Renal Cell Carcinoma: A Rare Renal Tumor.Journal of kidney cancer and VHL · 2014
    Article
  12. Tubulocystic renal cell carcinoma: Report of a rare case.Canadian Urological Association journal = Journal de l'Association des urologues du Canada
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Borislav A AlexievDepartment of Pathology, University of Maryland Medical Center, NBW85, 22 S Greene Street, Baltimore, MD 21201, USA. balexiev@umm.edu
Cinthia B Drachenberg

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tubulocystic carcinoma of the kidney (TCCK) is a tumor entity, which is not yet included in the WHO classification of renal tumors. The histogenesis of this neoplasm is uncertain. This study was undertaken to determine (1) the incidence of TCCK and (2) immunohistochemical and ultrastructural characteristics of those tumors that qualify as TCCK by the current definitions. From January 1, 2003 to December 31, 2012, a total of 615 renal cell carcinomas (RCCs) were seen by the Department of Pathology, University of Maryland Medical Center. Four TCCKs were identified (4/615, <1 %). TCCK is a distinctive group of kidney tumors with a male predominance and noteworthy macroscopic spongy appearance. Microscopically, the tumors were composed of tubules and cysts lined by a single layer of eosinophilic, columnar, cuboidal, flat, or hobnail cells with large nuclei and prominent nucleoli separated by a thin fibrotic stroma. In all TCCKs, the majority of neoplastic cells showed immunohistochemical (CD10(+), RCC(+), vimentin(+), and AMACR(+)) and ultrastructural (abundant long brush border microvilli) characteristics of proximal renal tubules. In few cells, the microvilli were shorter and sparse with cytoplasmic interdigitation analogous to intercalated cells of the collecting ducts. Focal positivity for BerEP4 (a marker preferentially expressed in distal renal tubules) was also noted. The major differential diagnostic considerations are oncocytoma, multilocular cystic renal cell carcinoma, and cystic nephroma/mixed epithelial and stromal tumor of the kidney. TCCK seems to have a favorable prognosis. In the current series, none of the patients had local recurrence or metastatic disease.

Indexed as

AdultAgedCarcinomaFemaleHumansImmunohistochemistryKidney NeoplasmsMaleMicroscopy, Electron, Transmission

Identifiers

PMID23525677

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.