ArticleInternational journal of legal medicine2013
Body fluid identification by mass spectrometry.
Article in International journal of legal medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06183385 (Detection of Specific Salivary Proteins by Immunoaffinity and Mass Spectrometry), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Detection of Specific Salivary Proteins by Immunoaffinity and Mass Spectrometry
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- Applications of Raman spectroscopy in the analysis of biological evidence.Forensic science, medicine, and pathology · 2024Pooled it
- Estimating bloodstain age using headspace gas chromatography-ion mobility spectrometry (HS-GC-IMS) and machine learning.International journal of legal medicine · 2026Article
- Identification of menstrual blood markers by proteomic mass spectrometry.International journal of legal medicine · 2026Article
- Standardizing a microbiome pipeline for body fluid identification from complex crime scene stains.Applied and environmental microbiology · 2025Article
- Proteomics for forensic identification of saliva and vomit in a case of alleged rape.Analytical and bioanalytical chemistry · 2025Article
- Applications of MALDI mass spectrometry in forensic science.Analytical and bioanalytical chemistry · 2024Review
- Detection of Oral Fluid Stains on Common Substrates Using SEM and ATR-FTIR Spectroscopy for Forensic Purposes.ACS omega · 2024Article
- Rescoring Peptide Spectrum Matches: Boosting Proteomics Performance by Integrating Peptide Property Predictors Into Peptide Identification.Molecular & cellular proteomics : MCP · 2024Review
- Discrimination of human and animal bloodstains using hyperspectral imaging.Forensic science, medicine, and pathology · 2024Article
- Development of a rapid, in-situ analysis method using sheath-flow probe electrospray ionisation-mass spectrometry for the direct identification of cocaine metabolites in dried blood spots.Rapid communications in mass spectrometry : RCM · 2023Article
- Advances in neuroproteomics for neurotrauma: unraveling insights for personalized medicine and future prospects.Frontiers in neurology · 2023Review
- Forensic Discrimination of Differentially Sourced Animal Blood Using a Bottom-Up Proteomics Based MALDI MS Approach.Molecules (Basel, Switzerland) · 2022Article
- On the Identification of Body Fluids and Tissues: A Crucial Link in the Investigation and Solution of Crime.Genes · 2021Review
- Forensic analysis of beverage stains using hyperspectral imaging.Scientific reports · 2021Article
- Species identification of semen stains by ATR-FTIR spectroscopy.International journal of legal medicine · 2021Article
- Pre-validation of a MALDI MS proteomics-based method for the reliable detection of blood and blood provenance.Scientific reports · 2020Article
- Transcriptomic Prediction of PigGenes · 2020Article
- Blood species identification based on deep learning analysis of Raman spectra.Biomedical optics express · 2019Article
- Article
- A mass spectrometry-based forensic toolbox for imaging and detecting biological fluid evidence in finger marks and fingernail scrapings.International journal of legal medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Standard methods for body fluid identification typically rely on detection of the functional proteins specific to or enriched in them, such as hemoglobin in blood, alkaline phosphatase and PSA in semen, or α-amylase in saliva. While these markers can be relatively specific, the multiple methods used to identify them frequently rely on nonspecific chemical, enzymatic, or antibody reactions that usually require the structural integrity of the markers and are not confirmatory because other proteins or substances can also give positive test results. Recent advances in proteomics and mass spectrometry offer the ability to simultaneously detect multiple body fluid protein markers in a single, confirmatory test. Here, multiple markers for blood, saliva, and semen are identified by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS). Data demonstrate the ability to detect these body fluids at nanoliter to subnanoliter levels and to distinguish mixtures. Protein stability of mock samples assayed after 16 months showed no diminution of signal. Because multiple peptides from multiple protein markers are detected and effectively sequenced by MALDI MS/MS, the assay is confirmatory. As mass spectrometry detects whatever peptides are present in a sample, no a priori knowledge of an unknown stain is necessary to perform the test.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.